Thanksgiving Day football is here again, and after a blip last year there are three NFL games to keep you entertained late into the night. The Saints (5-5) will host the Bills (6-4) at 8:20 p.m. ET, which caps a day that also includes the traditional home games for the Lions, who will host the Bears at 12:30 p.m. ET, and Dallas, which will host the Las Vegas Raiders at 4:30 p.m. ET. College football fans can also get their fix, with No. 8 Ole Miss heading to Starkville to take on arch-rival Mississippi State in the Egg Bowl at 7:30 p.m. ET.
The latest Week 12 NFL odds from Caesars Sportsbook have the Lions favored by 3.5. Dallas is a 7.5-point favorite at home in the NFL spreads, while the Bills are favored by 6.5. Mississippi State is favored by two in the latest college football odds from Caesars. Before you lock in your 2021 Thanksgiving Day football picks and parlays, be sure to see the latest 2021 Thanksgiving Day football parlay from the proven computer model at SportsLine.
The red-hot SportsLine Projection Model is on an astounding 130-91 run on top-rated NFL picks that dates back to the 2017 season, while it enters Week 13 of the college football season on a 39-25 run on its top-rated college football side picks.
Now, the model has intensely examined the latest NFL odds and college football betting lines, and the predictions are in. Head to SportsLine now to see the model's four-way Thanksgiving parlay that would pay 12-1.
Top Thanksgiving Day 2021 football predictions
One key piece to the 2021 Thanksgiving Day football parlay: The model is backing Ole Miss to cover the spread in Starkville. The road team is 5-1 against the spread in the last six meetings and Ole Miss won 31-24 in Oxford last season. That ran its all-time record to 63-45-6 in a series that dates to 1901. The Rebels have a star quarterback in Matt Corral and a trio of strong running backs. The offense ranks fifth in the nation in total yards (517.4 per game) and eighth in rushing (231.1). Corral has 3,100 passing yards and 552 rushing yards with a combined 29 TDs.
Corral is one of four players with more than 500 rushing yards, along with running backs Jerrion Ealy (643 yards, five TDS), Snoop Conner (561-11) and Henry Parrish (537-3). MSU's defense ranks seventh against the run but 68th against the pass, so receiver Dontario Drummond (876 yards, eight TDs) could see plenty of action. The Rebels are tied for fifth in the nation in turnover margin, taking the ball away 20 times. They also have 37 sacks, led by Sam Williams with 10, Cedric Johnson with 6.5 and Chance Campbell with six.
How to make Thanksgiving Day NFL, college football picks
The model also has jumped on all three NFL matchups and says one quarterback has a 99 percent chance of throwing a pick. Find out everything you need to know to complete your Thanksgiving Day parlays over at SportsLine.
So what are the four 2021 Thanksgiving Day football picks that could return a massive 12-1 payout if you parlay them together? Visit SportsLine now to see which quarterbacks will thrive and which will have a Thanksgiving Day to forget, all from a proven model with a history of crushing its football picks.