The Minnesota Vikings will look to respond from a rough outing at Philadelphia when they host the Detroit Lions on Sunday afternoon. Minnesota opened the season with a 23-7 win over Green Bay before losing to the Eagles in disappointing fashion last week. Detroit, meanwhile, is coming off an excellent performance, beating Washington 36-27.

Kickoff is set for 1 p.m. ET. Minnesota is favored by 6 points in the latest Vikings vs. Lions odds from Caesars Sportsbook, while the over/under is set at 52.5. Before entering any Lions vs. Vikings picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Vikings vs. Lions. You can head to SportsLine to see its picks. Here are several NFL betting lines for Lions vs. Vikings:

  • Vikings vs. Lions spread: Vikings -6
  • Vikings vs. Lions over/under: 52.5 points
  • Vikings vs. Lions picks: See picks here
Featured Game | Minnesota Vikings vs. Detroit Lions

Why the Vikings can cover

Minnesota couldn't get anything going at Philadelphia last week, but the Vikings will be comfortable returning home for a game against an opponent that they have dominated in recent years. The Vikings have won eight of the last nine meetings between these teams, covering the spread in six of those games. They have one of the NFL's best offenses, led by star wide receiver Justin Jefferson.

He piled up 184 receiving yards and two touchdowns in Week 1, and he is set up to have more success against a Detroit defense that has allowed 62 combined points in its first two games. The Vikings have also been excellent at home, going 4-1 straight up and against the spread in their last five contests. 

Why the Lions can cover

The comprehensive results of Detroit's first two games this season have been more impressive than Minnesota's. Detroit came up just short against Philadelphia in Week 1, covering the spread as a 6-point underdog. The Lions put together an even better performance last week, picking up a 36-27 win over Washington as 1-point underdogs. 

Quarterback Jared Goff threw for 256 yards and four touchdowns, while the rushing attack turned 24 carries into 191 yards. Minnesota is coming off a disastrous outing against Philadelphia, headlined by Cousins throwing three interceptions. Detroit has covered the spread in five of its last six games, while Minnesota has covered at a 7-13 clip in its last 20 games against NFC teams. 

How to make Vikings vs. Lions picks

The model has simulated Lions vs. Vikings 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Vikings vs. Lions? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to find out which side of the Lions vs. Vikings spread you need to jump on Sunday, all from the model that has crushed its NFL picks, and find out.