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The Dallas Cowboys will have the unenviable task of trying to contain Justin Jefferson when they visit the red-hot Minnesota Vikings on Sunday during the Week 11 NFL schedule. The 23-year-old Jefferson, who was the 22nd overall pick in the 2020 NFL Draft, is second in the league with 1,060 receiving yards and has racked up at least 98 in his last six contests. He leads all players with an average of 117.6 yards per game after registering 193 at Buffalo last week. The Cowboys are 1.5-point favorites in the latest Week 11 NFL odds at Caesars Sportsbook. Which Week 11 NFL lines should you target with your Week 11 NFL bets? Before you make any Week 11 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2022 NFL season on an incredible 153-108 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 11. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 11 NFL picks at SportsLine.

Top Week 11 NFL picks

After simulating every game 10,000 times, the model is high on the New York Giants (-3) to cover the spread against the Detroit Lions. Daniel Jones is coming off a performance against Houston in which he completed 13-of-17 pass attempts for 197 yards and a pair of touchdowns. That effort earned him a 153.3 passer rating, the highest mark in the NFL this season.

The sixth overall pick in the 2019 NFL Draft, Jones has committed only four turnovers in nine games this year after having 49 in 37 starts over his first three seasons in the league. The 25-year-old has gone six straight starts without an interception, the longest streak by a Giants quarterback since Phil Simms and longest active run in the NFL. That is one of the reasons New York is covering the spread in almost 60% of simulations. See which other NFL parlay picks to make here.

How to make Week 11 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing two underdogs that are projected to win outright. You can only see the model's NFL Week 11 best bets and parlay at SportsLine

What are the model's top Week 11 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 11 NFL best bets from a model on a 153-108 run on its top-rated picks, and find out.