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Two of the top teams in the AFC will headline the Week 12 NFL schedule when the Tennessee Titans (8-3) visit the New England Patriots (7-4). After starting as 5.5-point favorites in the opening Week 12 NFL odds on Caesars Sportsbook, the Patriots are now favored by a touchdown. Tennessee has only been a road underdog by seven points once before this season against the Los Angeles Rams, but the Titans won that game outright, 28-16.

The biggest inter-conference game on the Week 12 slate takes place at Lucas Oil Stadium, where the Tampa Bay Buccaneers (7-3) will square off against the Indianapolis Colts (6-5). The Colts have powered through early-season obstacles to become one of the most dangerous teams in the AFC, while the Buccaneers have lost two of their last three. The line hasn't moved off three points since it opened, but which side should you back with your Week 12 NFL bets and NFL parlays? Before making any Week 12 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 12. If you successfully parlay its picks, you'd be looking at a massive payout of 25-1. You can only see the model's Week 12 NFL picks at SportsLine

Top Week 12 NFL picks

After simulating every NFL game 10,000 times, the model is high on the Steelers to cover as three-point underdogs against the Cincinnati Bengals. It's difficult to beat the same team twice in the same season, and Cincinnati drew first blood in the meeting between the two in Week 3. Since then, the high-octane Cincinnati offense has down-shifted a gear and only put up 288 total yards against the Raiders last week.

The Bengals had allowed 1,265 yards of offense from Weeks 7 through 9. Pittsburgh has covered the spread in four of its five games as an underdog this season and will fight tooth-and-nail not to be defeated by Cincinnati again. SportsLine's model predicts that the Steelers keep the score within a field goal in well over 50 percent of all simulations.

How to make Week 12 NFL parlays

The model also jumped on four other matchups where it says the line is way off, including a divisional battle and a game between two teams fighting for their playoff lives. You can only see the model's NFL Week 12 best bets and parlay at SportsLine

What are the model's top Week 12 NFL picks? And which other matchups should you target for a 25-1 payout? Visit SportsLine now to see the Week 12 NFL best bets from a model on a 130-91 run on its top-rated picks, and find out.