The Philadelphia Eagles will try to get off to a 4-0 start for the first time since 2004 when they host former coach Doug Pederson and the Jacksonville Jaguars during the Week 4 NFL schedule. Philadelphia, which won its only Super Bowl title with Pederson at the helm in 2017, has scored at least 24 points in its first three games this season and has allowed a total of 15 in its last two contests. The Eagles began the all-time series against the Jaguars with a three-game losing streak, but have won the last three meetings, most recently posting a 24-18 road victory in 2018. Philadelphia is a 6.5-point favorite against Jacksonville in the latest Week 4 NFL odds at Caesars Sportsbook. Which Week 4 NFL lines should you target with your Week 4 NFL bets? Before you make any Week 4 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 4. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 4 NFL picks at SportsLine

Top Week 4 NFL picks

After simulating every game 10,000 times, the model is high on the Pittsburgh Steelers (-3.5) to win and cover against the New York Jets on Sunday. The Steelers have suffered back-to-back losses after opening the season with an overtime victory at Cincinnati, but they will have had nine days between games when they take the field against the Jets. Including playoffs, Pittsburgh has won 20 of its 26 all-time meetings with New York and 10 of 11 at home.

The Jets easily could be sitting with an 0-3 record since their only victory of 2022 came as a result of a 14-point outburst over the final 1:22 of the fourth quarter at Cleveland in Week 2. New York has surrendered at least 24 points in every contest thus far and is tied for 26th in the NFL with an average of 27 allowed, which is one reason Pittsburgh is covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 4 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing a pair of underdogs. You can only see the model's NFL Week 4 best bets and parlay at SportsLine

What are the model's top Week 4 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 4 NFL best bets from a model on a 139-103 run on its top-rated picks, and find out.