Two former Oklahoma quarterbacks who were drafted No. 1 overall will square off when Kyler Murray and the Arizona Cardinals take on Baker Mayfield and the Cleveland Browns on Sunday. The No. 1 pick in the 2018 draft, Mayfield has the Browns (3-2) in a tie for second place in the AFC North. Murray, the No. 1 pick in 2019, and the Cardinals (5-0) are the NFL's last remaining undefeated team. On Sunday, Arizona will be without coach Kliff Kingsbury, quarterback coach Cam Turner and defensive lineman Zach Allen, who all tested positive for COVID-19. Cleveland is a 3.5-point favorite in the latest NFL odds from Caesars Sportsbook, but which side should you back with your NFL bets and NFL parlays?

Other key NFL matchups include the four AFC division leaders squaring off: the Ravens hosting the Chargers on Sunday and the Bills meeting the Titans on Monday night. Before making any Week 6 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 6. If you successfully parlay its picks, you'd be looking at a massive payout of 25-1. You can only see the model's Week 6 NFL picks at SportsLine

Top Week 6 NFL picks

After simulating every NFL game 10,000 times, the model likes New England to cover as a four-point home underdog against Dallas. New England (2-3) is coming off a 25-22 victory over Houston in a game in which it trailed 22-9. Dallas is arguably the hottest team in the NFL, winning four straight after a season-opening loss at Tampa Bay.

The last time these teams met, Cowboys quarterback Dak Prescott had one of his worst games. In Week 12 of the 2019 season, Prescott completed just 19-of-33 passes for 212 yards, throwing an interception without a touchdown. His 64.2 passer rating in that game is Prescott's worst in any game since the start of 2019. That game continued a string of solid defensive performances by New England against Dallas. In the last five meetings between the teams, the Patriots have allowed just 11.6 points per game to the Cowboys.

How to make Week 6 NFL parlays

The model also jumped on four other matchups where it says the line is way off, including a divisional battle and a game between two playoff teams from a season ago. You can only see the model's NFL Week 6 best bets at SportsLine

What are the model's top Week 6 NFL picks? And which other matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on a 125-83 run on its top-rated picks, and find out.