The Giants put defensive ends Robert Ayers (pectoral) and Mathias Kiwanuka (knee) and offensive lineman Adam Snyder (knee) on season-ending injured reserve, reports ESPN.com.
Ayers suffered the injury Week 13 at Jacksonville. Kiwanuka sat out that game after recording 28 tackles and 2.5 sacks in the first 11 contests.
Giants cornerback Jayron Hosley, offensive lineman Justin Pugh, linebacker Jacquian Williams, guard Brandon Mosley, defensive end Mathias Kiwanuka, defensive lineman Cullen Jenkins and guard Adam Snyder were all ruled inactive Week 13 at Jacksonville.
The Giants have ruled out offensive lineman Adam Snyder (knee), defensive tackle Cullen Jenkins (calf) and linebacker Jacquian Williams (concussion, shoulder) for Sunday's game against the Jaguars. Defensive end Mathias Kiwanuka (knee) and tackle Justin Pugh (quadriceps) were the only two players deemed questionable.
Meanwhile, linebacker Jameel McClain (knee), safety Antrel Rolle (rest) and offensive lineman Geoff Schwartz (toe) were designated as probable for Week 13.
Giants coach Tom Coughlin said defensive lineman Mathias Kiwanuka (knee), guard Adam Snyder (knee) and linebacker Jameel McClain (knee) will not practice Wednesday. He added linebacker Jacquian Williams (concussion, shoulder), offensive tackle Justin Pugh (quadriceps) and defensive lineman Cullen Jenkins (calf) will be limited to individual drills.
The Giants are preparing to play the Jaguars in Week 13.
Giants coach Tom Coughlin said Monday he thinks offensive lineman Adam Snyder "will be fine" and "OK to play" Week 13 at Jacksonville after leaving Sunday's game due to a knee injury. Snyder made his first start of the season Week 12 vs. Dallas.
Giants guard Adam Snyder suffered a knee injury in his team's matchup with the Cowboys Sunday night and will not return, the team announced. However, tackle Will Beatty (eye) was able to return late in the fourth quarter after being deemed probable.
Giants linebacker Jacquian Williams, defensive tackle Cullen Jenkins, cornerback Mike Harris, guard Brandon Mosley, guard Adam Snyder, defensive end Kerry Wynn and tackle James Brewer were all ruled inactive Week 11 vs. San Francisco.
The Giants have listed Rashad Jennings, Mike Harris, Kerry Wynn, Adam Snyder, James Brewer, Brandon Mosley and Jay Bromley as inactive Week 10 against the Seahawks.
Jennings was considered doubtful coming into the contest due to a knee injury. Adam Snyder was listed as probable with a knee issue, but will not go. The other five players listed are healthy scratches.
Giants running back Rashad Jennings (knee) was the only player labeled doubtful heading into Sunday's game against the Seahawks in Seattle. The team released its final injury report Friday and the only players deemed questionable for Week 10 were Cullen Jenkins (calf), Mathias Kiwanuka (knee) and Zack Bowman (abdomen).
The following players were ruled probable: <span data-shortcode="annotation" data-id="1673483" data-text="Weston Richburg" data-canon="Weston Richburg" data-type="SPORTS_OBJECT_PLAYER" id="shortcode0"> (ankle), Adam Snyder (knee), Dominique Rodgers-Cromartie (back), Steve Weatherford (ankle) and Preston Parker (ankle).
The Giants have made RB Rashad Jennings, OL Adam Snyder, DE Kerry Wynn, OL James Brewer, OL Brandon Mosley, DT Jay Bromley and WR Corey Washington inactive Week 7 against the Cowboys.
Jennings was the only player listed on the injury report coming into the contest. He was ruled out prior to Sunday. The other six players are healthy scratches.
The Giants declared running back Rashad Jennings (knee), linebacker Spencer Paysinger (hamstring), offensive lineman Adam Snyder, defensive end Kerry Wynn, offensive tackle James Brewer, guard Brandon Mosley and defensive tackle Jay Bromley inactive for Sunday night's game at Philadelphia.
Giants wide receiver Julian Talley, linebacker Jon Beason, tackle Adam Snyder, tackle Charles Brown, defensive end Kerry Wynn, guard James Brewer and defensive tackle Jay Bromley were all ruled inactive Week 5 vs. Atlanta.
Giants wide receiver Odell Beckham (hamstring), linebacker Devon Kennard (hamstring), defensive tackle Markus Kuhn (ankle), tackle James Brewer (back), offensive lineman Adam Snyder, tackle Charles Brown and defensive end Kerry Wynn were all ruled inactive Week 2 vs. Arizona.
The Giants unveiled their inactives for Week 1 against the Lions. The following players were ruled inactive for the game: Odell Beckham, Adam Snyder,Charles Brown, Kerry Wynn, Markus Kuhn, Jay Bromley and James Brewer.
The Giants announced Wednesday they placed offensive lineman Geoff Schwartz on the injured reserve/designated to return list due to a dislocated right big toe. Schwartz is eligible to practice after six weeks and return to game action after eight weeks.
The team also announced it signed offensive lineman Adam Snyder to replace Schwartz on the active roster.
The 49ers made a slew of moves Saturday to pare their roster down to the required 53 for the regular season.
Among those moves was the placement of cornerback Kenneth Acker and fullback Will Tukuafu on the injured reserve list.
San Francisco cut the following players: T Carter Bykowski, TE Asante Cleveland, WR Lance Lewis, LS Kevin McDermott, CB Darryl Morris, G Al Netter, DL Lawrence Okoye, WR Kassim Osgood, T Michael Philipp, NT Mike Purcell, G Ryan Seymour, LB Shayne Skov, RB Alfonso Smith, G Adam Snyder, S C.J. Spillman, LB Chase Thomas, S Raymond Ventrone, WR L'Damian Washington and RB Glenn Winston.
49ers cornerback Tarell Brown (ribs), wide receiver Mario Manningham (knee), wide receiver Michael Crabtree (ankle), safety Craig Dahl (ankle), running back Frank Gore (ankle), defensive tackle Ray McDonald (ankle), linebacker Dan Skuta (foot), linebacker Aldon Smith (shoulder), defensive lineman Justin Smith (shoulder), guard Adam Snyder (not injury related) and tackle Joe Staley (knee) were all cleared to play Week 15 at Tampa Bay. Every player was listed as probable except Brown and Manningham, who were questionable.
The 49ers have listed WR Jon Baldwin, S Craig Dahl, DT Ray McDonald, LB Dan Skuta, LB Aldon Smith, DT Justin Smith, OL Adam Snyder and OL Joe Staley as probable Week 15.
Both Aldon and Justin Smith are dealing with shoulder injuries. Snyder is listed as a "non-injury" on the report.