| Conference Team Rankings | GF Average | GA Average | Power Play |
| Maple Leafs | 3.29 | 2.77 | 28.57% |
| Eastern | 2nd | 3rd | 1st |
* Tue Sep 18 | W 4 - 1 | OTT |
* Wed Sep 19 | W 4 - 1 | @OTT |
* Fri Sep 21 | W 5 - 3 | BUF |
* Sat Sep 22 | W 3 - 2 | @BUF |
* Mon Sep 24 7:30 pm ET | MON | |
* Wed Sep 26 7:30 pm ET | NHL | @MON |
* Fri Sep 28 7:30 pm ET | NHL | DET |
* Sat Sep 29 7:00 pm ET | @DET | |
| Wed Oct 3 7:00 pm ET | MON | |
| Sat Oct 6 7:00 pm ET | OTT | |
| Sun Oct 7 7:00 pm ET | @CHI | |
| Tue Oct 9 8:30 pm ET | @DAL | |
| Thu Oct 11 7:30 pm ET | @DET | |
| Sat Oct 13 7:00 pm ET | @WAS |
| EAST Atlantic | Overall W-L-OTL | Pts | |
 | Boston | 4-0-1 | 9 |
 | Toronto | 4-0-0 | 8 |
 | Detroit | 4-0-0 | 8 |
 | Montreal | 3-1-0 | 6 |
 | Buffalo | 2-2-0 | 4 |
 | Tampa Bay | 2-2-0 | 4 |
 | Florida | 2-2-0 | 4 |
 | Ottawa | 0-4-0 | 0 |
| Date | Player | Pos. | Injury |
| 9/21 | Travis Dermott | D | Questionable for start of season |
| 9/21 | Mason Marchment | LW | Questionable for start of season |
| 9/21 | Frederik Gauthier | C | Questionable for start of season |
| 9/22 | Zach Hyman | C | Questionable for start of season |
| Full injuries report | |||
