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A spot in the gold-medal match of the 2020 Tokyo Olympics men's tennis tournament will be on the line when Pablo Carreno Busta and Karen Khachanov square off in the semifinals at Ariake Tennis Park. Ranked No. 11 in the world, Carreno Busta has six career singles titles and is coming off an upset of No. 2 seed Daniil Medvedev in the quarterfinals. On Friday he will face Khachanov, who has four singles titles and took out Ugo Humbert in the quarters. The winner will face either world No. 1 Novak Djokovic or Alexander Zverev for the gold medal. 

The semifinal match is scheduled to begin at 2 a.m. ET. William Hill Sportsbook lists Carreno Busta as a -137 (risk $137 to win $100) favorite in the latest Carreno Busta vs. Khachanov odds, with Khachanov listed at +110 as the underdog. The over-under for total games is 22.5. Before making any Khachanov vs. Carreno Busta picks, you need to see the Olympics 2020 tennis predictions from esteemed handicapper Sean Calvert.

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. And earlier this month he nailed both of his bets for the Wimbledon men's singles final: Djokovic to win three sets to one (+275) and Djokovic to win and both players to win a set (+130). Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Olympics 2020 odds and released his best bets for Carreno Busta vs. Khachanov. He's sharing his Olympic tennis picks and analysis only at SportsLine.

Carreno Busta vs. Khachanov preview

Carreno Busta has done a great job in Tokyo of winning points with his second serve and converting break-point opportunities. In four matches at the Olympics, he has won 59 percent of his second serve points, which is better than the 55 percent that he has averaged so far this year on the ATP Tour. He also is converting 52 percent of his break-point chances, which is an improvement from his season average of 45 percent.

In addition, Carreno Busta has gotten the better of Khachanov in the few times they've played. The Spaniard is 3-2 lifetime against the Russian and emerged victorious in the players' only meeting this year, a 6-2, 6-3 win in Monte Carlo.

But Khachanov brings a red-hot game entering Friday. Earlier this month, the 25-year-old Russian reached the quarterfinals at Wimbledon, losing to Denis Shapovalov in a tight five-set match. He has ridden that good form so far in Tokyo, knocking off the eighth-seeded Diego Schwartzman and the 14th-seeded Humbert, among others.

And while Carreno Busta owns the career series 3-2, Khachanov has had the better of Carreno Busta on hard courts. The big-serving, 6-foot-6 righty has won two of the three matchups on hard courts, including the last two meetings. In those two matchups Khachanov hasn't even dropped a set.

How to make Carreno Busta vs. Khachanov picks

One of Calvert's picks is over 22.5 total games, but he has an even stronger play, which would pay close to 4-1. Be sure to check out Calvert's picks and analysis at SportsLine before making any Olympics 2020 picks of your own for the men's tennis semifinal.

Who wins Carreno Busta vs. Khachanov in the 2020 Olympics men's semifinal? And what wager that pays plus-money does Calvert like? Visit SportsLine now to see Sean Calvert's best bets for Khachanov vs. Carreno Busta, all from the tennis handicapper who called Wawrinka winning the 2014 Australian Open at 60-1, and find out.