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Group B winner Internacional is looking to kick off the first leg of the round of 16 the way it ended the group stage part of the 2021 Copa Libertadores on Thursday. Internacional defeated Olimpia Asuncion 1-0 to win Group B by one point over the Paraguayan team. It also posted a 6-1 victory over Olimpia Asuncion earlier in group stage play.

Internacional has been installed as a +138 favorite in the Olimpia Asuncion vs. Internacional odds from William Hill Sportsbook, while Olimpia Asuncion is a +320 underdog. Before you lock in your 2021 Copa Libertadores picks, make sure you check out the predictions and best bets from SportsLine and CBS Sports expert Roger Gonzalez.

Gonzalez grew up playing competitive soccer before becoming one of the world's foremost soccer journalists. After covering soccer all over the globe - a Champions League final in Italy, Copa America, and professional leagues in Argentina - Gonzalez returned to the U.S. as CBS Sports' top soccer expert. 

Now, Gonzalez has broken down the round of 16 and locked in his expert 2021 Copa Libertadores picks and predictions. You can head to SportsLine now to see his picks. Here are the Copa Libertadores 2021 odds and betting trends for Olimpia vs. Internacional:

  • Olimpia vs. Internacional spread: Internacional -0.5
  • Olimpia vs. Internacional over-under: 2.5 goals
  • Olimpia vs. Internacional moneyline: Olimpia +210, Internacional +138, Draw +220
  • OLI: Looking to advance to Copa Libertadores quarterfinals for first time since 2013
  • INT: Unbeaten in each of their last five away matches

Top 2021 Copa Libertadores predictions 

Gonzalez is confident who is going to win the Olimpia Asuncion vs. Internacional matchup, which begins at 8:30 p.m. ET. In the group stage of the event, Internacional outscored its opponents 12-5. Forward Thiago Galhardo powered the offense, scoring four goals in six matches. Also finding the net multiple times was midfielder Yuri Alberto, who scored three times in the five matches he played.

Even with two losses to Internacional, Olimpia Asuncion was able to punch its ticket to the round of 16, sweeping Always Ready and splitting with Deportivo Tachira, who they edged out by goal differential for second place. Midfielder Richard Ortiz is Olimpia's top goal scorer in the tournament with three. Midfielders Derlis Gonzalez and Isidro Pitta have scored twice each in limited action. Gonzalez played in just two matches, while Pitta played in four. Despite finishing second in Group B, Olimpia scored more goals in the stage than Internacional, outscoring them 13-12.

"While Olimpia has some quality, we can't forget that these two already met in the group stage. Inter won both meetings, including a 6-1 victory over the Paraguayans," Gonzalez told SportsLine. 

How to make 2021 Copa Libertadores picks 

Gonzalez has taken a look at the Olimpia vs. Internacional matchup from all angles and he's locked in his Copa Libertadores 2021 best bets, including one with a plus-money payout. He's only sharing his 2021 Copa Libertadores picks at SportsLine.

So which 2021 Copa Libertadores pick should you make on Thursday? And where does all the betting value lie? Visit SportsLine now to see Thursday's Olimpia Asuncion vs. Internacional Copa Libertadores 2021 pick, all from the expert who has crushed his soccer picks, and find out.