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Defending champion Bayern Munich and Lazio square off Tuesday in an intriguing Round of 16 match in the 2020-21 UEFA Champions League. Bayern Munich ran roughshod over the competition last year, including a 7-1 aggregate victory over Chelsea and 8-2 over Barcelona. The personnel hasn't changed a lot, but a 2-1 loss to Eintracht Frankfurt on Saturday proves it isn't unbeatable. Bayern scores a ton of goals but also yields its share, and Lazio has scoring options like dangerous striker Ciro Immobile to take advantage.

Kickoff from Rome's Stadio Olimpico is set for 3 p.m. ET. William Hill Sportsbook lists Bayern as a 0.5-goal and -129 money-line favorite in its latest Bayern Munich vs. Lazio odds, and the Over-Under for total goals scored is 3.5. Before making any Lazio vs. Bayern Munich picks, be sure to see the UEFA Champions League predictions and betting advice from SportsLine's proprietary European soccer model.

Created by two Norwegians -- professional poker player and sports bettor Jonas Gjelstad, and economics and engineering expert Marius Norheim -- the model analyzes worldwide betting data and exploits market inefficiencies, helping its followers cash in. Since coming to SportsLine in 2019, the algorithm is up more than $8,900.

The model also made some strong calls in the final group stage of the Champions League, correctly predicting RB Leipzig (+150) defeating Manchester United, Sevilla (+135) knocking off Rennes and Liverpool playing to a draw (+275) with Midtjylland.

Now, the model has set its sights on Lazio vs. Bayern Munich. You can visit SportsLine now to see the picks. Here are several odds and trends for Bayern Munich vs. Lazio:

  • Bayern Munich vs. Lazio spread: Bayern -0.5
  • Bayern Munich vs. Lazio over-under: 3.5 goals
  • Bayern Munich vs. Lazio money line: Bayern -129, Lazio +330
  • BM: F Kingsley Coman has three goals and two assists in four UCL matches.
  • LAZ: F Ciro Immobile has five goals in the six Champions League games.

Why you should back Bayern Munich

As it proved in last year's Champions League title run, scoring is the bread and butter for Bayern. Robert Lewandowski and Thomas Muller are the catalysts, with Lewandowski leading the Bundesliga with 26 goals and Muller and Bayern teammate Joshua Kimmick tied at the top with 10 assists. Bayern has 62 goals in 22 league games, with a goal differential of 31.

The defense suffers from the constant attacking, but it has experienced players in the middle with David Alaba and Jerome Boateng, and Manuel Neuer is one of the best goalkeepers in the sport's history. Kingsley Coman (nine assists) and Leroy Sane (seven assists, four goals) also make big contributions to the offense and have combined for five goals in four UCL matches.  

Why you should back Lazio

Immobile has the speed and finishing ability to exploit Bayern Munich on the counter-attack. Bayern has conceded 31 goals in 22 matches, so Lazio shouldn't have a lot of trouble getting on the scoreboard. Lazio has scored in 22 of its 23 games in Serie A action and has not been held off the score sheet since October. Immobile is tied for third in Serie A with 14 goals. 

Sergej Milinkovic-Savic is a critical piece to the Lazio attack, tying for the league lead with eight assists and chipping in five goals. Luis Alberto can also do damage, posting seven goals, including the winner in a 1-0 victory against Sampdoria the last time out. Lazio's defense has limited high-powered attacks in Serie A, and goalkeeper Pepe Reina is as experienced as they come. 

How to make Champions League picks for Lazio vs. Bayern Munich

The model is leaning under on the total, and it has also locked in its projected final score and spread pick. You can only get these picks at SportsLine

So who wins Bayern Munich vs. Lazio? And where does all the betting value lie? Visit SportsLine now to find out which side of the Lazio vs. Bayern Munich money line has all the value, all from the proprietary European soccer model that's up more than $8,900.