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With its third Premier League title in four seasons all but secured, Manchester City can put most of its focus on the 2021 UEFA Champions League. The Cityzens are 11 points ahead of second-place Manchester United, who have seven games remaining, as they attempt to reach the Champions League semifinals for the first time in five campaigns. Manchester City can accomplish that feat when it visits Borussia Dortmund on Wednesday for the second leg of the 2021 UEFA Champions League quarterfinals. The Cityzens gained the upper hand in the tie with a 2-1 home triumph in the first leg, thanks to a goal by Phil Foden in the 90th minute.

Kickoff from Signal Iduna Park is scheduled for 3 p.m. ET. The latest Borussia Dortmund vs. Manchester City odds from William Hill Sportsbook list Manchester City as a 0.5-goal favorite, while the over-under for total goals scored is 3.5. Before locking in any Manchester City vs. Borussia Dortmund picks, be sure to see the UEFA Champions League predictions and betting advice from SportsLine's proprietary European soccer model.

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Created by two Norwegians -- professional poker player and sports bettor Jonas Gjelstad, and economics and engineering expert Marius Norheim -- the model analyzes worldwide betting data and exploits market inefficiencies, helping its followers cash in. Since coming to SportsLine in 2019, the algorithm is up over $8,200.

Now, the model has set its sights on Borussia Dortmund vs. Manchester City. You can visit SportsLine now to see its picks. Here are several odds and trends for Manchester City vs. Borussia Dortmund:

  • Borussia Dortmund vs. Manchester City spread: Man City -0.5
  • Borussia Dortmund vs. Manchester City over-under: 3.5 goals
  • Borussia Dortmund vs. Manchester City money line: Man City -150, Dortmund +380, Draw +310
  • BVB: Dortmund has lost six consecutive matches against English teams
  • CITY: The Cityzens have scored 54 goals in their last 22 Champions League games

Top Champions League predictions for Dortmund vs. Manchester City

The model is leaning under 3.5 goals in Wednesday's matchup between Borussia Dortmund and Manchester City. The Cityzens are one of the best defensive teams on the planet, as they've allowed a total of 29 goals in 49 matches across all competitions this season and only two in nine Champions League games. However, their offense has been stalling a bit of late, recording fewer than three goals in each of the last five outings, and their top scorers have not been producing. Ilkay Gundogan (team-high 16 goals) has been contained in back-to-back matches after scoring in five of his previous six and Raheem Sterling (13) has tallied once in his last 10 games and enters Wednesday on a four-game drought.

Gabriel Jesus (13) has scored just one goal in four contests while the first-leg tally by Foden (12) is the only one he's registered in his last 12 outings. Erling Haaland has been outstanding for Dortmund, scoring a total of 33 goals in 34 overall matches this season while leading the Champions League with 10 goals. However, the 20-year-old forward is mired in a six-game drought after posting five two-goal performances over his previous eight contests and Jadon Sancho has gone three straight Champions League matches without a goal, which is one of the reasons the model is leaning toward the under on Wednesday.

How to make Champions League picks for Dortmund vs. Manchester City

The model also has locked in a strong money-line pick for Borussia Dortmund vs. Manchester City. You can only get that pick at SportsLine.

So who wins Manchester City vs. Borussia Dortmund? And where does all the betting value lie? Visit SportsLine now to find out which side of the Borussia Dortmund vs. Manchester City money line has all the value, all from the proprietary European soccer model that's up over $8,200.