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After a wild couple of weeks of international matches, domestic competitions return this weekend with some huge games from Europe to MLS to down in South America. This weekend features important clashes in Italy, tasty showdowns in England and some really intriguing battles as the playoffs loom in the NWSL.

Ahead of this weekend's games, here are our picks for the matches you should definitely make sure not to miss:

5. Leverkusen vs. Bayern Munich

Date: Sunday, Oct. 17 | Time: 9:30 a.m. ET
Live stream: ESPN+
Caesars Sportsbook Odds: Leverkusen +400; Draw +340; Bayern -167

Why watch: It's a clash at the top of the table as Bayern face Leverkusen with the two teams level on points atop the Bundesliga. A win for the underdogs, Leverkusen, will put them in sole possession of first place as the top four are separated by just a point. These are the two highest scoring teams in the league so far so it has the chance to be a goal fest. 

4. Lazio vs. Inter Milan

Date: Saturday, Oct. 13 | Time: 12 p.m. ET
TV and live stream: Paramount+
Caesars Sportsbook Odds: Lazio +240; Draw +215; Inter +124

Why watch: A top six battle in Italy with Lazio looking to escape a funk of just one win in their last four. Inter have the best attack in Italy at the moment, averaging over three goals per game. Both teams have legit title aspirations, and this would be a statement for either.

3. Brentford vs. Chelsea

Date: Saturday, Oct. 13 | Time: 12:30 p.m. ET
TV: NBC | Live stream: fuboTV (Try for free)  
Caesars Sportsbook Odds: Brentford +525; Draw +270; Chelsea -165

Why watch: The surprises of the season, Brentford, go to first-place Chelsea in one of the games of the weekend in England. Two stellar defenses, a wild crowd at Brentford Community Stadium and the potential to be an instant classic. After beating Arsenal, can Brentford knock off another London big boy?

2. Leicester vs. Manchester United

Date: Saturday, Oct. 16 | Time: 10 a.m. ET
TV: USA | Live stream: fuboTV (Try for free)  
Caesars Sportsbook Odds: Leicester +245; Draw +255; United +108

Why watch: Winless in their last four, Leicester need to get it going as they sit in 13th place. A win against fourth-place Manchester United could be it. Both defenses have inexcusable lapses from time to time, and there is so much quality in the midfields that this could be quite the chess match.

1. Juventus vs. Roma

Date: Sunday, Oct. 17 | Time: 2:45 p.m. ET
TV and live stream: Paramount+
Caesars Sportsbook Odds: Juve -112; Draw +260; Roma +310F

Why watch: Juve and Roma square off in a game with so many storylines. Jose Mourinho gets his first crack at Juve since joining Roma, American Weston McKennie looks to find some solid form and Roma look to potentially boost their top-four chances after a promising start. Five of their last six meetings have featured multiple goals, and the expectation is for that to continue here. 

Honorable mentions

(All times U.S./Eastern)

Friday, Oct. 15: A game to watch in ... 

  • France: PSG vs. Angers, 3 p.m. (beIN Sports and fuboTV -- Try for free)
  • Germany: Hoffenheim vs. Koln, 2:30 p.m. (ESPN2 and fuboTV -- Try for free)
  • Argentina: Defensa y Justicia vs. Estudiantes, 8:15 p.m. (Paramount+)

Saturday, Oct. 16 A game to watch in ...

  • MLS: Torono FC vs. Atlanta United, 7:30 p.m. (ESPN+)
  • England: Aston Villa vs. Wolves, 10 a.m. (NBCSN)
  • Spain: Real Sociedad vs. Mallorca, 3 p.m. (ESPN+)
  • Italy: Milan vs. Hellas Verona, 2:45 p.m. (Paramount+)
  • Germany: Borussia Dortmund vs. Mainz, 9:30 a.m. (ESPN+)
  • France: Lyon vs. Monaco, 3 p.m. (beIN Sports and fuboTV -- Try for free)  
  • Argentina: Huracan vs. Boca Juniors, 7:15 p.m. (Paramount+)
  • Brazil: America Mineiro vs. Bahia 8 p.m. (Paramount+)
  • NWSL: OL Reign vs. Washington Spirit, 10 p.m. (Paramount+)

Sunday, Oct. 17 A game to watch in....

  • MLS: NY Red Bulls vs. NYCFC, 1 p.m. (ESPN and fuboTV -- Try for free)  
  • England: Everton vs. West Ham, 9 a.m. (NBCSN and fuboTV -- Try for free)  
  • Spain: Barcelona vs. Valencia, 3 p.m. (ESPN+)
  • Italy: Napoli vs. Torino, 12 p.m. (Paramount+)
  • Germany: Augsburg vs. Arminia Bielefield, 11:30 a.m. (ESPN+)
  • France: Marseille vs. Lorient, 2:45 p.m. (beIN Sports and fuboTV -- Try for free)   
  • Argentina: River Plate vs. San Lorenzo, 7:15 p.m. (Paramount+)
  • Brazil: Palmeiras vs. Internacional, 3 p.m. (Paramount+)
  • NWSL: Houston Dash vs. Portland Thorns, 7 p.m. (Paramount+)