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Both teams advanced in the FA Cup on Saturday, and now Tottenham and Southampton will square off on Wednesday in an English Premier League match. Spurs (11-3-6) are fighting for one of the top-four spots, sitting in seventh place but not far behind No. 4 West Ham. Tottenham has games in hand, and Spurs have lost just once in their last 10 league matches. Tottenham beat Brighton 3-1 in an FA Cup fourth-round match Saturday, while Southampton edged Coventry City 2-1. The Saints are in 12th place but are starting to score a lot more goals.

Kickoff at Tottenham Hotspur Stadium in London is set for 2:45 p.m. ET. Tottenham is the -185 favorite (risk $185 to win $100) on the 90-minute money line in Caesars Sportsbook's latest Tottenham vs. Southampton odds. Southampton is the +525 underdog, a draw is priced at +310 and the over-under for total goals scored is 2.5. Before you lock in your Southampton vs. Tottenham picks, you need to see what proven soccer insider Jon Eimer has to say

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, Eimer has covered the English Premier League, Serie A, the FA Cup and much more. The Indiana-based handicapper compiled a winning record of 260-133-1 with over 90 units of profit for his community on various platforms over a recent two-month stretch.

Now, Eimer has broken down Tottenham vs. Southampton from all sides and just locked in his coveted picks and EPL predictions. You can head to SportsLine now to see his picks. Here are the betting lines and trends for Southampton vs. Tottenham:

  • Tottenham vs. Southampton spread: Tottenham -1.5 (+150)
  • Tottenham vs. Southampton over-under: 2.5 goals 
  • Tottenham vs. Southampton money line: Tottenham -185, Southampton +525, Draw +310 
  • TOT: GK Hugo Lloris is tied for fourth in the EPL with eight clean sheets 
  • STH: Defender Mohammed Salisu leads the league in clearances (128)

Why you should back Tottenham

Spurs have not played a league game at home since Boxing Day, and the crowd will be ready to go. They have won five straight against the Saints in London, and they are 7-1-2 in home matches this season. Tottenham has scored 16 goals and given up 10 in the 10 matches, while the Saints have been conceding left and right in road fixtures. Southampton are 2-3-6 in away games, allowing 24 goals. That will be a major problem against a Spurs team featuring Harry Kane and a healthy Son Heung-Min.   

Kane scored twice in the win against Brighton, and the 2021 Golden Boot winner (23 goals) has been heating up. He has scored four of his five goals in league play in the past 10 matches, and he has 13 goals in all competitions. Spurs' only loss in its past 10 EPL games was its most recent, a 2-0 setback to third-place Chelsea, so it will be eager to get on another roll. Son has eight league goals, and Lucas Moura has scored six in all competitions. 

Why you should back Southampton

The Saints are 4-3-1 in their last six games overall, including a 1-1 draw with Spurs on Dec. 28. They have shown all year they can hang with the top teams, drawing twice with Man City and playing to stalemates with Manchester United and West Ham. They also beat the Hammers 3-2 on Boxing Day. The Saints have taken six points in the past eight league meetings (2-2-4). 

James Ward-Prowse scored the goal in the December game, and he has a team-high six goals. Kyle Walker-Peters scored early against City and also had a goal in Saturday's FA Cup win. Southampton has scored 17 goals in the past eight matches, while Tottenham has conceded in six straight. Che Adams (four goals) is always a threat, and 24-year-old Adam Armstrong (two goals) has yet to break out but has the potential to do so at any time. Armstrong scored 28 goals with Blackburn last season.     

How to make Tottenham vs. Southampton picks

Eimer has scrutinized Tottenham vs. Southampton from all sides, and he is leaning over on the goal total. He also provides his three confident best bets, including a confident play on the winner, and has a full breakdown of the match. He's only sharing his expert EPL picks at SportsLine.

So who wins Southampton vs. Tottenham? And where does all the betting value lie? Visit SportsLine now to see the best bets for Tottenham vs. Southampton, all from the soccer expert who has his finger on the pulse of the game all over the world, and find out.