Tennis: Wimbledon
Susan Mullane / USA TODAY Sports

Defending champion Rafael Nadal and five-time champ Roger Federer won't participate when the 2020 U.S. Open starts Monday from Flushing Meadows, N.Y. But that doesn't mean it will be easy for Novak Djokovic, the world's top-ranked player and a three-time U.S. Open winner himself. Djokovic recently dealt with pain in his neck, causing him to pull out of doubles last Sunday at the Western & Southern Open, the tournament that served as a U.S. Open warm-up at the USTA Billie Jean King National Tennis Center.

Djokovic remains the -125 favorite (risk $125 to win $100) in the latest 2020 U.S. Open odds from William Hill, followed by Daniil Medvedev (6-1), Stefanos Tsitsipas (7-1), Dominic Thiem (7-1), Milos Raonic (20-1), Alexander Zverev (25-1) and Roberto Bautista Agut (25-1). Before you make any 2020 U.S. Open picks or tennis predictions, see what renowned tennis handicapper Sean Calvert has to say.

Calvert is the famed handicapper who took down a huge score on Dominic Thiem winning Indian Wells at 80-1 last year. He's racked up seven straight profitable seasons betting tennis. 

At Wimbledon last year, Calvert told his followers to grab 3-1 odds on Djokovic facing Federer in the final, adding Djokovic would win it all. The result: Djokovic and Federer cruised into the finals, with Djokovic winning the longest men's singles final in tournament history for his fifth Wimbledon crown. Anyone who followed Calvert's advice was handsomely rewarded.

And Calvert owns the U.S. Open. Since 2013, $100 bettors who have followed his U.S. Open picks are up a whopping $8,540.

Now, Calvert has broken down the latest U.S. Open 2020 odds and released his coveted best bets to win it all. Head to SportsLine to see them.

Top 2020 U.S. Open predictions

For the U.S. Open 2020, we can tell you Calvert is fading Thiem in a big way. The 26-year-old Austrian prefers slower courts than the new surface in New York. That was evident last Monday in Thiem's dismal straight-sets loss to Filip Krajinovic. The world's No. 3 player fell to 9-4 this calendar year.

Although Thiem enters the U.S. Open 2020 as the highest-ranked player besides Djokovic, Calvert says there are far better values than the 7-1 odds Thiem is getting.

How to make 2020 U.S. Open picks

Instead, Calvert is backing two other players to win, including a long shot whose draw sets up perfectly for a stunning run. This overlooked pro is surging at the right time and could deliver a monster payout. Find out who it is, and see all of Calvert's picks and analysis, over at SportsLine.

So who wins the U.S. Open 2020? Which massive long shot stuns the tennis world? Visit SportsLine now to see Sean Calvert's coveted U.S. Open picks, all from the renowned expert who's returned over $8,500 on his U.S. Open bets, and find out.