Daniil Medvedev can register a career-changing victory on Sunday when he takes on one of the greatest players of all-time, Novak Djokovic, in the final of the 2021 Australian Open. Ranked No. 4 in the world, the 25-year-old Medvedev is looking to win his first career grand slam title. He has previously played in only one other major final, losing to Rafael Nadal in the 2019 U.S. Open. Standing in Medvedev's way is Djokovic, who has won 17 grand slams, including a record eight Australian Opens.

The match is set to begin at 3:30 a.m. ET. William Hill Sportsbook lists Djokovic as a -118 favorite in the latest Djokovic vs. Medvedev odds, while Medvedev is a +100 underdog. There are a variety of other Medvedev vs. Djokovic props available like total games, with the over-under set at 39.5. Before making any Djokovic vs. Medvedev picks, be sure to see the 2021 Australian Open predictions from famed tennis handicapper Sean Calvert.

Calvert is the tennis expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. 

Earlier this week, Calvert nailed his two bets in the quarterfinal between Djokovic and Alexander Zverev: first set tiebreak (+180) and over 41.5 total games (+115). He also correctly called Stefanos Tsitsipas to upset Nadal in the quarterfinal, which paid +275. Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Australian Open 2021 odds and released his coveted best bets for Medvedev vs. Djokovic. He's sharing his analysis at SportsLine.

Novak Djokovic vs. Daniil Medvedev preview

No grand slam brings out the best in Djokovic more than the Australian Open. In his 17 appearances in Melbourne, the 33-year-old Serb owns an 81-8 record, while his 91.0 winning percentage is his best at any of the four majors. His second best winning percentage is at Wimbledon (87.8).

This year, Djokovic has been ruthless in attacking second serves. In his six matches in Melbourne, he has won 127 second serve return points, the most in the 2021 Australian Open bracket and 24 more than Medvedev.

Medvedev enters the final in career-best form. The 6-foot-6 Russian with a blistering backhand has won 20 consecutive matches, a streak that includes wins over players ranked No. 1 (Djokovic), No. 2 (Nadal) and No. 3 (Dominic Thiem), as well as eight others in the top 10. During the streak, Medvedev has dropped just seven sets.

His return game has been particularly sharp in Melbourne. In his six matches Down Under, he has won 123 points when returning first serves and 103 when returning second serves. Both totals rank second in the 2021 Australian Open bracket.

How to make Medvedev vs. Djokovic picks

Calvert has analyzed the match and released his best bets, including one that would pay more than 4-1. Be sure to see Calvert's analysis before locking in your Australian Open 2021 picks for the men's finals.

Who wins Medvedev vs. Djokovic? And which prop could lead to a huge return? Visit SportsLine now to see Calvert's best bets for Medvedev vs. Djokovic, all from the famed tennis handicapper who called Wawrinka winning the 2014 Australian Open at 60-1.