The 2021 Australian Open continues Tuesday with a high-profile matchup between Daniil Medvedev and Andrey Rublev in the men's quarterfinals. The battle, which starts at 11 p.m. ET, pits a pair of top-seven seeds who are both playing at a dominant level to this point in the tournament. Medvedev and Rublev both hail from Russia, with familiarity breeding additional intrigue in this Australian Open 2021 matchup. Rublev is also looking for his first win against his countryman.

William Hill Sportsbook lists Medvedev as the -275 favorite (risk $275 to win $100), while Rublev is listed the underdog at +210 (risk $100 to win $210). There are a variety of additional Medvedev vs. Rublev picks on the board as well like total match games, with the over-under set at 39.5. Before making any Medvedev vs. Rublev picks, be sure to see the latest 2021 Australian Open predictions from tennis expert Sean Calvert.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is way up.

Now, Calvert has locked in on the 2021 Australian Open men's quarterfinal matchup featuring Medvedev vs. Rublev and revealed his best bets. Head to SportsLine now to see them.

Daniil Medvedev vs. Andrey Rublev preview

On top of the fascinating and impressive play of Medvedev and Rublev, observers can also take solace in the angle of the two being rivals and teammates. They are teammates for the ATP Cup and, though Medvedev has the upper hand in their career matchups, winning all three, no secrets should exist in this matchup.

In fact, both players are unbeaten in 2021, with Medvedev arriving on an 18-match winning streak dating back to November. The two matched up in the 2020 U.S. Open, with Medvedev outlasting the challenger.

Medvedev has been lights-out at breaking serve on 38.1 percent of occasions. Rublev has been stellar in service, holding serve on 93.4 percent of occasions. He is also known for his tenacity and ferocious play, providing an interesting and entertaining contrast to the stoic Medvedev.

How to make Medvedev vs. Rublev picks

Calvert is highly confident he knows who wins this matchup and also has a full breakdown of what to expect. Be sure to see Calvert's picks and analysis over at SportsLine before locking in your 2021 Australian Open picks for the men's quarterfinals.

Who wins Rublev vs. Medvedev in the Australian Open 2021 men's quarterfinal? And what pick could lead to a big return? Visit SportsLine now to see Calvert's best bets for Medvedev vs. Rublev, all from the acclaimed expert who called the 2014 Australian Open at 60-1.