Jennifer Brady and Jessica Pegula had increasingly looked forward to this day since they arrived in Melbourne, and it will finally come on Tuesday at 9 p.m. ET when the friends face off in the 2021 Australian Open quarterfinals. The Americans used their messages written on the TV camera lenses after victories to spur each other on, and they will meet for just the second time in their careers with a spot in the final four on the line. Brady has cruised through her four matches without losing a set, while Pegula has faced a much more difficult road to her first major quarterfinal.

The latest Brady vs. Pegula odds from William Hill Sportsbook list Brady as the -250 favorite (risk $250 to win $100), while Pegula is getting +190 as the underdog (risk $100 to win $190). There are numerous other Brady vs. Pegula picks you can make, including a +110 play on Brady to win it in two sets or +470 for Pegula to take it in three.

Before you make your 2021 Australian Open women's quarterfinals picks, you need to check out the 2021 Australian Open predictions from famed tennis handicapper Gavin Mair.

Mair is the international women's tennis expert who called unseeded Jelena Ostapenko (80-1) winning the 2017 French Open, Naomi Osaka (32-1) winning the 2018 U.S. Open, Bianca Andreescu (20-1) winning the 2019 U.S. Open, plus many other spot-on calls.

Before the women's singles final in the most recent Grand Slam, the French Open, Mair picked Iga Swiatek to win (-163) in straight sets (+140), and he was right on both counts, as the 19-year-old beat Simona Halep for her first title.

Now, Mair has broken down the latest 2021 Australian Open women's quarterfinals odds and released his coveted best bets for Pegula vs. Brady. He's sharing all his picks and analysis right here.

Brady vs. Pegula preview

Mair knows Brady is one of the best servers in the women's game, and Mair has seen her make quick work of her opponents in Melbourne. She lost only 11 games in her first three matches and pressured Donna Vekic into 20 unforced errors in the first set of a 6-1, 7-5 victory in the fourth round. Her 114 mph serve is tough to handle, and she has 27 aces in five matches in 2021.

This is the second quarterfinals appearance for Brady in her last three majors, and she lost to Naomi Oska in three sets in the U.S. Open semifinals. She has the fitness to play all over the court and can hit her high-topspin forehands and two-handed backhands for winners. She also won't hesitate to come to the net to finish off her points, a skill she has honed in doubles play. 

Pegula, on the other hand, is in the midst of a storybook run, and her familiarity with Brady could make her first quarterfinal a little easier. They have been exclusive practice partners since arriving in Australia and paired up in doubles at the Billie Jean King Cup in 2019. She has one career victory, at the 2019 Washington Open, and beat Brady in their only previous matchup.

Pegula came in with three match wins at major tournaments, but she has gotten past two-time Australian champion Victoria Azarenka and 2011 U.S. Open champ Sam Stosur. She notched her first top-10 victory in the fourth round, beating fifth-seeded Elina Svitolina 6-4, 3-6, 6-4.

How to make Brady vs. Pegula picks

Is Brady powerful enough to stop Pegula's storybook run? Mair has released confident picks on the winner, as well as advice on game handicap and set betting. Be sure to see Mair's picks and analysis before making your Australian Open 2021 picks for the women's quarterfinals.

Who wins Pegula vs. Brady in the 2021 Australian Open women's singles quarterfinal? And what pick could lead to a big return? Visit SportsLine now to see Gavin Mair's best bets for Brady vs. Pegula, all from the acclaimed expert who hit big in the last Grand Slam women's final.