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The 2021 French Open continues on Wednesday with a full slate of intriguing tennis action. On the men's side, a quarterfinal match between Novak Djokovic and Matteo Berrettini should provide great interest. Djokovic, the No. 1 player in the world, could face a tangible challenge, with the match scheduled to begin at 2 pm ET. Roland Garros hosts Wednesday's showdown, with the winner projected to face the top clay court player in the world in Rafael Nadal.

Djokovic is listed as a -600 favorite (risk $600 to win $100) in the latest Djokovic vs. Berrettini odds from William Hill Sportsbook, with Berrettini getting +400 (risk $100 to win $400) as the underdog. William Hill set the over-under for total games at 34.5, with the top seed favored by 6.5 games. Before making any 2021 French Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert

Calvert is the renowned handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is way up.

Now, Calvert has locked in on the 2021 French Open men's quarterfinal matchup featuring Djokovic vs. Berrettini and revealed his best bets. Head to SportsLine to see them.

Top Djokovic vs. Berrettini predictions

Djokovic, as the top-ranked player in the world, has a full arsenal and it has been on display in this tournament in previous iterations. He has reached the quarterfinals in 15 of his 17 appearances at Roland Garros. While clay is not his best surface, he entered as the player with the second-best odds to win the tournament and has lived up to that. Djokovic also holds a win in the only previous meeting between these two players, topping Berrettini on an indoor hardcourt surface in 2019 by a final margin of 6-2, 6-1.

Berrettini holds the rest advantage and decisively so. He advanced through the fourth round with a walk-over after Roger Federer was forced to exit. As such, he hasn't played since Saturday and, if this match goes long, that could be a major benefit. The dryer conditions at Roland Garros this week have also benefited Berrettini, particularly when it comes to a dominating serve that can be an X-factor.

How to make Berrettini vs. Djokovic picks

Calvert has made the call on the over-under for total games and he's found a prop bet he loves that returns almost 3-1. Head to SportsLine to see his best bets

Who wins Berrettini vs. Djokovic in the French Open 2021 men's quarterfinal? And what other pick could lead to a big return? Visit SportsLine now to see Sean Calvert's best bets, all from a renowned tennis handicapper, and find out.