All eyes will be on Rafael Nadal on Wednesday as he continues his 2021 French Open journey with a quarterfinal match against Diego Schwartzman. Nadal entered the tournament as a strong favorite to garner yet another title at Roland Garros, and a win in this match could set up a high-stakes battle against Novak Djokovic. Djokovic takes on Matteo Berrettini in another quarterfinal match in the French Open 2021 later on Wednesday. The Nadal vs. Schwartzman match is set for a 9 a.m. ET start time at Roland Garros.

Nadal enters as a -2500 favorite (risk $2500 to win $100) in the latest Nadal vs. Schwartzman odds from William Hill Sportsbook, with Schwartzman sitting at +1000 (risk $100 to win $1000) as the underdog in the latest 2021 French Open odds. William Hill Sportsbook sets the over-under for total games at 28.5, with Nadal favored by 9.5 games. Before making any 2021 French Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert

Calvert is the renowned handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is way up.

Now, Calvert has locked in on the 2021 French Open men's quarterfinal matchup revealing his Nadal vs. Schwartzman picks and best bets. Head to SportsLine to see them.

Top Nadal vs. Schwartzman predictions

As the all-time wins leader at Roland Garros, Nadal is a significant favorite in this match for a reason. He boasts a 104-2 career record in this event, and Nadal is a 13-time champion. To this point, he has not lost a set in the tournament, though it should be noted that he trailed and faced relative peril in the first set against Jannik Sinner in the fourth round. Nadal also owns a 10-1 career record over Schwartzman, and he has been dominant with his second serve in previous matches against this opponent.

Schwartzman does own a clay court victory over Nadal, with a win in Rome during 2020. While Schwartzman lost five of his previous seven matches on clay before arriving at Roland Garros, he is playing improved tennis on the whole, particularly in service games. There could be room for early optimism with regard to the first set, as Nadal has scuffled out of the gates in a few matches, notably so against Sinner.

How to make Schwartzman vs. Nadal picks

In addition to the winner, Calvert has released two other strong bets: a specific pick for the number of sets and whether the match goes over or under 28.5 games. Head to SportsLine to see his French Open best bets.

Who wins Schwartzman vs. Nadal in the 2021 French Open men's quarterfinal? And what other pick could lead to a big return? Visit SportsLine now to see Sean Calvert's best bets for Nadal vs. Schwartzman, all from the renowned tennis expert who has made some huge calls.