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No. 5 seed Stefanos Tsitsipas faces No. 6 seed Alexander Zverev in a highly-anticipated match on Friday at the 2021 French Open. The standout players square off in one of the men's semifinal matches, with the winner advancing to Sunday's final. Tsitsipas advanced with a quarterfinal win over No. 2 seed Daniil Medvedev, while Zverev toppled Alejandro Davidovich Fokina in his last match. Roland Garros hosts the match at 8:50 a.m. ET, with all eyes on the red clay as the French Open 2021 heads into the final weekend.

The latest 2021 French Open odds from William Hill Sportsbook list Tsitsipas as a -250 favorite (risk $250 to win $100), while Zverev is going off as the +190 underdog. The over-under for total games is set at 37.5, and Tsitsipas is the -4.5 favorite in the game handicap, according to the latest Tsitsipas vs. Zverev odds. Before making any 2021 French Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert

Calvert is the renowned handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks has seen some huge returns.

Now, Calvert has locked in on the 2021 French Open men's semifinal matchup featuring Zverev vs. Tsitsipas and revealed his best bets. Head to SportsLine to see them.

Top Tsitsipas vs. Zverev predictions

This profiles as a highly-entertaining matchup between players that are playing top-level tennis. Both were betting favorites to emerge from their quarters of the draw before the tournament started and, for the most part, Tsitsipas and Zverev have lived up to the billing. 

Zverev is riding a 13-match winning streak and, after a hiccup that led to a two-set deficit in the opening round, he has won 15 straight sets. Zverev has been notably aggressive during the tournament, especially in coming to the net and dictating the style of matches, and that helps to explain his success.

Tsitsipas owns the 5-2 advantage in this head-to-head battle all-time, and he also won the only previous matchup on a clay surface. Like Zverev, he is red-hot right now, posting a 21-3 record on clay this season. Tsitsipas also overcame a top-flight player in  Medvedev in the quarterfinal, avenging a stretch in which he lost six of seven matches to Medvedev. Tsitsipas is quite strong on clay, and that has manifested in the recent past, including a stellar 59 percent second serve rate on the surface this season.

How to make Zverev vs. Tsitsipas picks

In addition to the winner, Calvert has released other strong best bets, including one that returns almost 3-1. Be sure to see Calvert's picks and analysis before locking in your French Open picks 2021 for the men's semifinals

Who wins Tsitsipas vs. Zverev in the French Open 2021 men's semifinal? And what other pick could lead to a big return? Visit SportsLine now to see Sean Calvert's best bets for Tsitsipas vs. Zverev, all from the tennis handicapper who's made some huge calls in men's tennis.