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No. 18 Maria Sakkari looks to derail defending champion Iga Swiatek in a quarterfinal matchup at the 2021 French Open on Wednesday at approximately 6:15 a.m. ET. Swiatek, who won the tournament a year ago, is the odds-on-favorite to win the event. She has three career victories and is ranked No. 9 in the world. Sakkari, meanwhile, has one WTA singles championship and is ranked No. 18.

William Hill Sportsbook lists Swiatek as the -450 favorite (risk $450 to win $100) on the money line, while Sakkari is at +320 in the latest Swiatek vs. Sakkari odds. The latest 2021 French Open odds list the total number of games expected at 19.5. Before making any Sakkari vs. Swiatek picks, see the 2021 French Open predictions from elite tennis handicapper Gavin Mair.

A renowned women's tennis handicapper, Mair cashed in huge at last year's French Open. He picked Iga Swiatek to win (-163) and win in straight sets (+140), and he was right on both counts.

He also called unseeded Jelena Ostapenko (80-1) winning the 2017 French Open, Naomi Osaka (32-1) winning the 2018 U.S. Open and Bianca Andreescu (20-1) winning the 2019 U.S. Open.

Now, Mair has broken down the latest 2021 French Open odds from William Hill and released a pair of best bets for this matchup. Head to SportsLine to see them.

Iga Swiatek vs. Maria Sakkari preview

Mair sees Swiatek as nearly unbeatable on clay. Not only has she won her last 11 matches at the French Open, but she has not dropped a set in any of those. 

Sakkari, who is making her third straight grand slam appearance, has won 60 percent of her career singles matches after turning pro in 2015. Although she lost in the first round of the Australian Open, she rebounded with a quarterfinal appearance in Doha, losing in straight sets to eventual champion Garbine Muguruza. She also lost in the final at the Miami Open.

The tennis expert knows Sakkari has an aggressive, all-court style of play, which is centered on her strong serve. She also has powerful groundstrokes. She served the sixth-most aces of any player a year ago, with 144 in 31 matches.

Swiatek also has an all-court style of play. Her game is focused on offense, which leads to a high amount of both winners and unforced errors. She turned pro in 2016 and played in her first grand slam event in 2019, when she competed at the Australian Open. The 2021 French Open is her ninth grand slam event of her career.

How to make Sakkari vs. Swiatek picks

Mair has revealed a pair of best bets for this matchup, including a strong play on the exact outcome. Be sure to see Mair's picks and analysis before locking in your 2021 French Open picks.

Who wins Sakkari vs. Swiatek in the French Open 2021? And which prop bet should you be all over? Visit SportsLine right now to see Gavin Mair's best bets, all from the acclaimed expert who has owned this tournament.