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All eyes in the tennis world will be on Arthur Ashe Stadium in Flushing Meadows on Thursday evening. Both women's semifinal matches are scheduled to take place at the 2021 U.S. Open, and each brings significant intrigue. The finale of the night features a matchup between Emma Raducanu and Maria Sakkari that is scheduled to begin at approximately 8:15 pm ET. The winner earns a trip to the final to face either Aryna Sabalenka or Leylah Annie Fernandez for a grand slam title.

Caesars Sportsbook lists Sakkari as the -162 favorite (risk $162 to win $100), while Raducanu is the +130 underdog in the latest Sakkari vs. Raducanu odds. The over-under for total games is set at 21.5 in the latest 2021 U.S. Open odds. Before making any 2021 U.S. Open picks, be sure to see the latest tennis predictions from SportsLine's Gavin Mair

A renowned women's tennis handicapper, Mair has cashed in huge at previous U.S. Open tournaments. He called Naomi Osaka (32-1) winning the 2018 U.S. Open and Bianca Andreescu (20-1) winning the 2019 U.S. Open. He also held a position on semifinalist Belinda Bencic (50-1) at the 2019 edition, and he nailed a +550 position on the second set of the 2021 Wimbledon final. Anyone who followed Mair's advice was handsomely rewarded.

Now, Mair has locked in on the 2021 U.S. Open women's semifinal matchup featuring Raducanu vs. Sakkari and revealed his best bets. Head to SportsLine to see them.

Top Raducanu vs. Sakkari predictions

Sakkari, who entered as the No. 17 seed in the field, enters as the betting favorite, and she also holds an experience advantage. She is renowned for her physical strength on the court, and Sakkari has been dominant with her serve. Sakkari won 22 straight service points in a quarterfinal win over No. 4 seed Karolina Pliskova, and she will rely on that weapon against the red-hot play of Raducanu. 

In Raducanu, Sakkari will face an 18-year-old breakout star. She has defeated a trio of top-50 opponents in New York, including an upset win over Belinda Bencic, the gold medalist at the 2020 Olympics in Tokyo. Raducanu has not lost a set in the main draw of the U.S. Open, and only one set has gone to five-all for the youngster. She holds a career 8-1 record in grand slam play following a Round of 16 appearance at Wimbledon earlier this year. Raducanu must neutralize Sakkari's serve, and she is known for her strategic, counter-attacking style of play.

How to make Sakkari vs. Raducanu picks

Mair has studied this matchup in-depth and locked in two best bets, including a strong play on the winner. Head to SportsLine to see his best bets

Who wins Raducanu vs. Sakkari in the U.S. Open 2021 women's semifinal? And which picks should you be all over? Visit SportsLine now to see Gavin Mair's best bets, all from a renowned tennis handicapper, and find out.