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The 2022 French Open continues on Friday with a pair of interesting semifinal matchups on the men's side. The first match is the headliner, with Rafael Nadal taking on Alexander Zverev in a face-off between top-five seeds in the tournament. Nadal knocked off Novak Djokovic in the quarterfinal, with Zverev using four sets to defeat Carlos Alcaraz. The Nadal vs. Zverev match is scheduled to begin at 8:45 a.m. ET at Roland Garros.

Nadal is a -330 favorite (risk $330 to win $100) in the latest Nadal vs. Zverev odds from Caesars Sportsbook, with Zverev getting +250 (risk $100 to win $250) as the underdog. Caesars sets the over-under for total games at 36.5, with Nadal favored by 5.5 games. Before making any 2022 French Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In the Miami Open in 2018, he did even better, correctly calling 100-1 long shot John Isner to win the title. And in 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. Anyone following his picks is way up.

Now, Calvert has locked in on the 2022 French Open men's semifinal matchup featuring Nadal vs. Zverev and revealed his best bets. Head to SportsLine to see them.

Rafael Nadal vs. Alexander Zverev preview

Zverev enters this matchup in impressive form. The No. 3 seed ended a 14-match winning streak for Alcaraz in the quarterfinal, and he reached the final of the Madrid Open and the semifinal of the Monte Carlos Masters and Italian Open this season. Zverev used his serve as a huge weapon against Alcaraz, winning 73 percent of points on his first serve, and is the reigning Gold Medal winner at the 2020 Olympics in Tokyo. Zverev has also won three of the last four matches against Nadal, including a win at Madrid.

Though Nadal is coming off two marathon matches that taxed his aging frame, he is a one-of-a-kind competitor. The 13-time French Open champion is now 110-3 overall at Roland Garros in his career. Nadal is 4-1 against Zverev on clay and 6-3 overall, with impressive service numbers and an elite defense against Zverev's power. From there, Zverev struggles at times with consistency, and Nadal is a famous grinder, with all eyes on whether he can land his 22nd grand slam title.

How to make Nadal vs. Zverev picks

Calvert has broken down this match, and his best bet returns more than 3-1. Be sure to see Calvert's picks and analysis at SportsLine before making your French Open 2022 picks for the men's semifinal.

Who wins Zverev vs. Nadal in the 2022 French Open men's semifinal? And what pick that returns more than 3-1 should you be all over? Visit SportsLine now to see Sean Calvert's best bets for Nadal vs. Zverev, all from the tennis handicapper with a history of making big calls.