One player will reach the first ATP Masters 1000 final of his career when Casper Ruud of Norway and Francisco Cerundolo of Argentina collide in the semifinals of the 2022 Miami Open on Friday afternoon at Hard Rock Stadium in Miami Gardens, Fla. Ranked No. 8 in the world, Ruud pulled off the biggest upset of his career when he knocked off No. 2 seed Alexander Zverev in the quarterfinals on Wednesday. Ruud is the highest-ranked player remaining in the draw. He will face the lowest ranked player remaining, Cerundolo (No. 103), who already has clinched the biggest paycheck ($343,985) of his career. The winner will advance to Sunday's final and face the winner of Hubert Hurkacz vs. Carlos Alcaraz Garfia.

The semifinal is set to begin at 1 p.m. ET. Ruud is a -600 favorite (risk $600 to win $100) in the latest Ruud vs. Cerundolo odds from Caesars Sportsbook, while Cerundolo is a +420 underdog. Before locking in any Cerundolo vs. Ruud picks or props, you need to see the 2022 Miami Open predictions and betting advice from internationally acclaimed tennis expert Sean Calvert.

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In the Miami Open in 2018, he did even better, correctly calling 100-1 long shot John Isner to win the title. And in 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Miami Open 2022 odds and released his coveted best bets for the Ruud vs. Cerundolo semifinal. He's only sharing his picks and expert tennis analysis at SportsLine.

Casper Ruud vs. Francisco Cerundolo preview

Ruud recorded a couple of firsts just to reach the semifinals. His victory over Zverev in the quarterfinals was the first of his career over the German; he had lost their two previous meetings. In addition, the win marked the first time Ruud had advanced beyond the quarterfinals in a Masters 1000 hard court tournament; he had lost in his three previous opportunities.

Now Ruud must record another first: a win in a Masters 1000 semifinals match. He is winless in three previous attempts, all on clay. 

Meanwhile Cerundolo has made an unlikely run to the semifinal. The native of Argentina has specialized on clay courts during his four-year professional career. The deepest run he's made at the Tour level came last year in Buenos Aires, when he reached the final, losing to countryman Diego Schwartzman.

Cerundolo has had a strong 2022, winning an ATP Challenger Tour title on clay before reaching the semifinals in Rio de Janeiro. Prior to Miami he held an 0-2 record on hard courts at the Tour level, but so far in South Florida he has knocked off the likes of Gael Monfils (seeded No. 22) and Frances Tiafoe (No. 28). Two other opponents, Reilly Opelka and Jannik Sinner, retired mid-match.

How to make Cerundolo vs. Ruud picks 

Calvert is leaning under 20.5 total games (-105), but he has an even stronger play on the semifinal match. Be sure to see Calvert's pick and analysis before making your Miami Open 2022 picks for the men's semifinal.

Who wins Ruud vs. Cerundolo in the 2022 Miami Open men's semifinal? And what wager does Calvert like? Visit SportsLine now to see Sean Calvert's best bet for Cerundolo vs. Ruud, all from the tennis handicapper who called Isner winning the 2018 Miami Open at 100-1.