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Federer shakes hands with Alexandr Dolgopolov of Ukraine after Dolgopolov retired early on Tuesday at Wimbledon. Getty Images

Centre Court at Wimbledon resembled a triage unit on Tuesday as previous champions Roger Federer and Novak Djokovic both advanced without much work. Federer earned his record-breaking 85th match win at Wimbledon to move in to the second round after just 43 minutes of action because his opponent, Alexandr Dolgopolov, stopped in the second set with an injury. Federer was leading 6-3, 3-0 at the time.

The owner of seven Wimbledon titles and 18 Grand Slam trophies in all improved to 85-11 for his career at Wimbledon. That moved him one win ahead of Jimmy Connors for most victories in the grass-court major in the Open era, which began in 1968.

Djokovic advanced to the second round at Wimbledon after just 40 minutes when his opponent, Martin Klizan, retired because of an injury while trailing 6-3, 2-0.

Djokovic, a three-time champion at the All England Club, was leading 30-0 in the third game of the second set when Klizan, from Slovakia, decided he couldn't continue.

Klizan entered the tournament with a left ankle injury and took a medical timeout between sets. He was broken in the first game of the second set and, minutes later, stopped.

Djokovic won at Eastbourne last week, marking the first time since 2010 he had played a grass-court event prior to Wimbledon. He will next face Adam Pavlacek in the second round.

In the women's draw, last year's runners-up were up first on the main showcourts at Wimbledon on Tuesday, and both came through in straight sets.

Angelique Kerber, playing in the spot on Centre Court normally reserved for the defending women's champion, beat Irina Falconi of the United States 6-4, 6-4. On No. 1 Court, Milos Raonic defeated Jan-Lennard Struff of Germany 7-6 (5), 6-4, 7-6 (4).

"A lot of memories came back when I walk on the Centre Court," Kerber said. "Playing there again, it's one of the best courts to play. It's traditional, so it was really great to being back."

Kerber stepped in to the opening spot on Centre Court on Day 2 in place of Serena Williams, the defending champion who is out for the rest of the season because she is pregnant.

Although Kerber became the first women seeded No. 1 in the professional era to lose in the first round of the French Open, she made it through to the second round on the grass.

"Playing first rounds in Grand Slams are always tough, especially with my first-round match that I lost in Paris," Kerber said. "I was actually just thinking about point by point, trying to finding my rhythm during the whole match."

Djokovic followed on Centre Court, leading 6-3, 2-0 when Klizan stopped because of injury. The second-seeded Serb was leading 30-0 in the third game of the second.

The victory put Djokovic alone into second place on the list of Grand Slam match wins, one ahead of Jimmy Connors, with 234.

Juan Martin del Potro needed seven match points, but he also advanced, beating Thanasi Kokkinakis 6-3, 3-6, 7-5 (2), 6-4.

Other winners include 2015 Wimbledon finalist Garbine Muguruza among the women, and 15th-seeded Gael Monfils among the men.

The Associated Press contributed to this story