When Thome made it 2-all in the third with his fourth home run, he remained the only White Sox player to clear the fences this season. In the sixth, Crede ended the non-Thome homer drought and put the White Sox ahead. Konerko restored their two-run lead in the eighth.
"I knew we were going to hit," said Freddy Garcia, who gave up three runs and five hits over six innings for his 100th win. "We have a great lineup."
Thome, who has been used solely as a designated hitter, was acquired from Philadelphia in November for outfielder Aaron Rowand and two pitchers. Thome hit just seven homers in 59 games last season, limited by elbow and back injuries.
"As long as Jim is healthy, we know he can help this ballclub," Chicago manager Ozzie Guillen said. "Being a DH will help him because it keeps him out of the field."
The last time the White Sox played at Comerica Park was Sept. 29, when they clinched the AL Central en route to their first World Series title since 1917.
"I think that game set everything up for the playoffs," Guillen said. "People were talking a lot of stuff about us, about how we choke, but after we clinched here, it took a lot of pressure off the players."
Garcia (1-1) bounced back with a solid outing after allowing seven runs and nine hits over four innings in his first start, a loss to Cleveland.
Chicago has won two straight after losing four in a row.
Jeremy Bonderman (1-1) allowed four runs and six hits in seven innings for the Tigers. Detroit has lost two straight following a 5-0 start under new manager Jim Leyland.
"It was a good ballgame -- just a bad outcome," Leyland said.
Leyland, who led Florida to the 1997 World Series title and was a two-time NL Manager of the Year in Pittsburgh, is back in the dugout for the first time since quitting in Colorado following the 1999 season.
His 15th season as a major league manager is with the Tigers, who signed him as a minor league catcher in 1963 and he began his career in the dugout in 1971 with Detroit's farm team in the Appalachian League.
After Sparky Anderson chose to not include Leyland on his coaching staff in the late 1970s, Leyland left to be the White Sox third-base coach in 1982. A Comerica Park-record crowd of 44,179 gave him perhaps the loudest pregame ovation.
"I don't know if they will Wednesday, but that was a good feeling," Leyland said of the cheers.
Detroit went ahead 2-0 on Craig Monroe's two-run homer in the second inning, one pitch after Carlos Guillen walked. Thome tied the game in the third with a two-run shot, homering for the second straight day.
Chicago took a 4-2 lead with another two-out homer, Crede's in the sixth. Chris Shelton's RBI double pulled the Tigers within a run in the home half.
- Thome's homer was his 434th, tying Juan Gonzalez for 34th. Thome is seventh among active players.
- Detroit closer Todd Jones, on the 15-day DL with a pulled left hamstring, threw off a mound and said he felt good.
- Through their first seven games, the Tigers haven't committed an error -- their best streak to start a season since 1951.
- Detroit native Jerome Bettis, who helped the Pittsburgh Steelers win the Super Bowl next door at Ford Field, threw out the ceremonial first pitch.
- The White Sox were 14-5 against Detroit last season.
- Shelton was selected the AL player of the week Monday.