When Thome made it 2-all in the third with his fourth home run, he remained the only White Sox player to clear the fences this season. In the sixth, Crede ended the non-Thome homer drought and put the White Sox ahead. Konerko restored their two-run lead in the eighth.
"I knew we were going to hit," said Freddy Garcia, who gave up three runs and five hits over six innings for his 100th win. "We have a great lineup."
Thome, who has been used solely as a designated hitter, was acquired from Philadelphia in November for outfielder Aaron Rowand and two pitchers. Thome hit just seven homers in 59 games last season, limited by elbow and back injuries.
"As long as Jim is healthy, we know he can help this ballclub," Chicago manager Ozzie Guillen said. "Being a DH will help him because it keeps him out of the field."
The last time the White Sox played at Comerica Park was Sept. 29, when they clinched the AL Central en route to their first World Series title since 1917.
"I think that game set everything up for the playoffs," Guillen said. "People were talking a lot of stuff about us, about how we choke, but after we clinched here, it took a lot of pressure off the players."
Garcia (1-1) bounced back with a solid outing after allowing seven runs and nine hits over four innings in his first start, a loss to Cleveland.
Chicago has won two straight after losing four in a row.
Jeremy Bonderman (1-1) allowed four runs and six hits in seven innings for the Tigers. Detroit has lost two straight following a 5-0 start under new manager Jim Leyland.
"It was a good ballgame -- just a bad outcome," Leyland said.
Leyland, who led Florida to the 1997 World Series title and was a two-time NL Manager of the Year in Pittsburgh, is back in the dugout for the first time since quitting in Colorado following the 1999 season.
His 15th season as a major league manager is with the Tigers, who signed him as a minor league catcher in 1963 and he began his career in the dugout in 1971 with Detroit's farm team in the Appalachian League.
After Sparky Anderson chose to not include Leyland on his coaching staff in the late 1970s, Leyland left to be the White Sox third-base coach in 1982. A Comerica Park-record crowd of 44,179 gave him perhaps the loudest pregame ovation.
"I don't know if they will Wednesday, but that was a good feeling," Leyland said of the cheers.
Detroit went ahead 2-0 on Craig Monroe's two-run homer in the second inning, one pitch after Carlos Guillen walked. Thome tied the game in the third with a two-run shot, homering for the second straight day.
Chicago took a 4-2 lead with another two-out homer, Crede's in the sixth. Chris Shelton's RBI double pulled the Tigers within a run in the home half.
|Joe Crede and Paul Konerko join the party with their first home runs of the season. (AP)|
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|Chicago White Sox|
|Scott Podsednik, LF||4||0||0||0||0||1||1|
|Tadahito Iguchi, 2B||4||1||2||0||0||2||0|
|Jim Thome, DH||4||1||1||2||0||2||2|
|Paul Konerko, 1B||3||2||2||1||1||0||0|
|Jermaine Dye, RF||4||0||0||0||0||1||2|
|A.J. Pierzynski, C||4||0||0||0||0||0||2|
|Joe Crede, 3B||3||1||1||2||1||0||0|
|Rob Mackowiak, CF||4||0||0||0||0||3||2|
|Brian Anderson, CF||0||0||0||0||0||0||0|
|Alex Cintron, SS||4||0||1||0||0||0||0|
|Juan Uribe, SS||0||0||0||0||0||0||0|
|2B - Paul Konerko (, Bonderman)|
|HR - Jim Thome (, Bonderman), Paul Konerko (, Zumaya), Joe Crede (, Bonderman)|
|RBI - Jim Thome 2 (), Paul Konerko (), Joe Crede 2 ()|
|2-OUT RBI - Jim Thome 2 (), Joe Crede 2 ()|
|Team LOB - 4|
|DP - Konerko-Cintron|
|E - Scott Podsednik (, Misplayed grounder)|
|Chicago White Sox|
|Freddy Garcia (W,-)||6||5||3||3||2||5||1|
|Brandon McCarthy (H,)||2||2||0||0||0||0||0|
|Bobby Jenks (S,)||1||0||0||0||0||1||0|
|Pitches-Strikes - Freddy Garcia 93-60, Brandon McCarthy 19-16, Bobby Jenks 9-7|
|Ground Balls-Fly Balls - Freddy Garcia 3-10, Brandon McCarthy 2-3, Bobby Jenks 2-0|
|Batters Faced - Freddy Garcia 25, Brandon McCarthy 7, Bobby Jenks 3|
|Curtis Granderson, CF||4||0||0||0||0||1||1|
|Placido Polanco, 2B||4||0||0||0||0||0||1|
|Ivan Rodriguez, C||4||1||2||0||0||0||0|
|Magglio Ordonez, RF||4||0||1||0||0||1||2|
|Dmitri Young, DH||4||0||1||0||0||1||2|
|Chris Shelton, 1B||4||0||1||1||0||2||1|
|Carlos Guillen, SS||2||1||0||0||2||0||1|
|Craig Monroe, LF||4||1||2||2||0||0||2|
|Brandon Inge, 3B||3||0||0||0||0||1||1|
|2B - Dmitri Young (, Garcia), Chris Shelton (, Garcia)|
|HR - Craig Monroe (, Garcia)|
|RBI - Chris Shelton (), Craig Monroe 2 ()|
|2-OUT RBI - Chris Shelton (), Craig Monroe 2 ()|
|SB - Ivan Rodriguez (, 2nd base off Garcia/Pierzynski), Dmitri Young (, 3rd base off Garcia/Pierzynski)|
|Team LOB - 5|
|Jeremy Bonderman (L,-)||7||6||4||4||2||8||2|
|Pitches-Strikes - Jeremy Bonderman 101-65, Jamie Walker 4-2, Joel Zumaya 18-13|
|Ground Balls-Fly Balls - Jeremy Bonderman 4-9, Jamie Walker 1-0, Joel Zumaya 2-2|
|Batters Faced - Jeremy Bonderman 29, Jamie Walker 1, Joel Zumaya 6|
|Attendance - 44179|
|Game Time - 2:14|
|Temperature - 54|
|Umpires - Home - Brian Gorman, First Base - Eric Cooper, Second Base - Bill Miller, Third Base - Gerry Davis|