CINCINNATI -- Ken Griffey Jr. needed just one swing to remind everybody of his Hall of Fame credentials.
Griffey, in his first appearance after missing 17 games with a toe injury, hit a 1-1 pitch from left-hander Scott Eyre (1-3) into the right-field seats for his 27th homer this season and 563rd of his career, tying Reggie Jackson on the home run list.
"That's why he's in the Hall of Fame -- or will be," Reds manager Jerry Narron said.
It was the fifth pinch-hit homer of Griffey's career. The next player to catch on the home-run list is Rafael Palmeiro at No. 9 with 569.
Griffey hadn't played since dislocating the second toe of his right foot while trying to climb the wall and catch a homer by Barry Bonds on Sept. 4 at Great American Ball Park. Monday's homer was his first in 39 at-bats since Aug. 25 at San Francisco.
"I'm still part of this team," said Griffey, who limped around the bases and answered a curtain call. "I still can help the team, mentally or physically.
"Reggie's always been pretty good to me," he said. "The things he's done -- it's an honor in itself. I'd like to have the title 'Mr. October.' I think everybody in the locker room would like to have that title."
Eyre, who struck out Adam Dunn to end Cincinnati's two-run seventh, got Edwin Encarnacion to ground out to start the eighth. Brandon Phillips walked and Norris Hopper delivered a pinch-hit single. David Ross struck out, and Griffey, who was 7-for-20 with three home runs in his career against Eyre, batted for pitcher Scott Schoeneweis.
"I was going to come up a couple of innings before that, but they didn't get to me," Griffey said. "They said, 'If a guy gets on, you're hitting.' I was really trying not to embarrass myself."
"Griffey's a pretty amazing guy," said Chicago manager Dusty Baker, who also managed Bonds in San Francisco. "He hasn't swung the bat in a couple of weeks. Only him and Barry Bonds could do that. I wouldn't have minded if he stayed on the bench for the rest of my career."
Schoeneweis (2-0) got two outs in the eighth to earn the win. David Weathers pitched the ninth for his team-leading 12th save.
Griffey's homer cost Wade Miller his first win since beating Kansas City 8-5 for Boston on Aug. 3, 2005. The right-hander, in his fourth start after missing the first five months of the season because of shoulder surgery, allowed three hits and three walks.
Cincinnati put at least one runner on base in every inning against Miller, but none got past second base.
Bronson Arroyo lasted seven innings, giving up only four hits and no earned runs with two walks and five strikeouts. The right-hander, Miller's teammate with the Red Sox last season, fell short in his second try at a career-high 15 wins. He won 14 with Boston last season.
"That's one of those no-decisions that feels like a win," Arroyo said.
The Cubs took advantage of errors on back-to-back batters to score four unearned runs in the first inning. Shortstop Rich Aurilia was unable to make a barehanded grab of Matt Murton's slow grounder, loading the bases. Angel Pagan hit a one-hopper to Arroyo, but Ross dropped Arroyo's throw to the plate, allowing Juan Pierre to score. Aramis Ramirez scored on John Mabry's groundout, and Henry Blanco lined a two-run single to left.
Aurilia broke up the shutout with a two-run single to right off Michael Wuertz with the bases loaded in the seventh.
- Weathers celebrated his 37th birthday Monday.
- Reds infielder Juan Castro signed a two-year contract extension through 2008.
- The Reds finished 42-39 at home for the second consecutive season. They drew 2,134,472, an average of 26,352. Their total attendance was an increase of 16,278 over last season.
- The Cubs finished 30-51 on the road, their worst road record since going 27-54 in 2000.