Chicago's hopes of a first-round upset over the Celtics have suffered a major blow.

The Bulls announced Friday that point guard Rajon Rondo is out indefinitely after suffering a fractured right thumb during Tuesday's Game 2. The injury will not require surgery.

This is devastating news for Chicago, which has seen its offense hit a new level with Rondo, Dwyane Wade and Jimmy Butler developing a newfound chemistry at the perfect time.

After averaging 7.8 points, 6.7 assists and 5.1 rebounds during the regular season, Rondo has upped his averages to 11.5 points, 10 assists and 8.5 rebounds in two postseason games. He has caused a problem for the Celtics by getting into the lane and either finding shooters or finishing himself.

This is exactly the kind of thing that the Celtics were hoping for, as they desperately look for something to turn this series around. Without Rondo, the Bulls will use the point guard tandem of Jerian Grant and Michael Carter-Williams, with Grant reportedly earning the start.

The Bulls could also give the majority of ball-handling duties to Wade and Butler, as the team waits to see if Rondo can return before the end of the series.

Tip off for Game 3 is set for Friday at 7 p.m. ET.