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Mitchell sustained a calf injury and will not return to Saturday's wild-card game at Houston, Andrew Walker of the Colts' official site reports.
Mitchell battled a calf issue throughout the second half of the season and he appeared to aggravate the injury on a blitz before being helped off the field by trainers. The Colts' three-man safety rotation will continue with Malik Hooker, Clayton Geathers and George Odum
