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The New York Yankees (28-10) host the Chicago White Sox (19-19) early Saturday afternoon to start off their three-game series. Friday's matchup was postponed to due inclement weather. Chicago is currently 1-3 against New York on the season. New York is 14-4 at Yankee Stadium on the year. Dallas Keuchel (2-3, 5.54 ERA) gets the start for Chicago. Nestor Cortes (2-1, 1.35 ERA) is on the hill for New York.

First pitch is set for 1:05 p.m. ET. New York is the -215 favorite (risk $215 to win $100) on the money line in the latest Yankees vs. White Sox odds from Caesars Sportsbook, while Chicago is a +185 underdog. The over-under for total runs scored is nine. Before making any White Sox vs. Yankees picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has set its sights on Yankees vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the picks. Here are several MLB odds and trends for White Sox vs. Yankees: 

  • Yankees vs. White Sox money line: Yankees -215, White Sox +185
  • Yankees vs. White Sox run line: Yankees -1.5 (-115)
  • Yankees vs. White Sox over-under: 9 runs
  • Yankees vs. White Sox tickets: See tickets at StubHub
  • CHW: White Sox are 6-1 in their last seven Saturday games
  • NYY: Yankees are 22-7 in their last 29 during Game 1 of a series
Featured Game | New York Yankees vs. Chicago White Sox

Why you should back the Yankees

Designated hitter Giancarlo Stanton is a big-time slugger in the lineup for New York. Stanton is capable of driving the ball out of any yard with ease. The four-time All-Star additionally can play either corner outfield position. Stanton leads the team in RBIs (35) along with 11 home runs and a batting average of .296. In his previous contest, he was 2-for-3 with a solo home run and three runs driven in.

Shortstop DJ LeMahieu is a solid batter who makes consistent contact. LeMahieu owns good speed, athleticism and power. The three-time All-Star has good instincts with quick reaction times on the defensive end. LeMahieu's batting average is .267 with two homers and 13 RBIs. 

Why you should back the White Sox

Shortstop Tim Anderson is a fantastic athlete and talent for the White Sox. Anderson has quick hands and bat speed, allowing him to turn on a pitch in a blink of an eye. He's a sound defender with a solid throwing arm. The three-time All-Star also has some nice pop in his swing. Anderson leads the team in batting average (.346), on-base percentage (.386), and hits (47) along with 15 RBIs. On May 18, he was 3-for-5 with three singles and one run was driven in.

Center fielder Luis Robert is an important part of the lineup. Robert is a quick and versatile defender with great recovery speed in the outfield. The 24-year-old has a smooth-looking swing with home run power. Robert ranks first on the squad in homers (6) and RBIs (17) with a batting average of .301. In his last outing, he went 3-for-4 with a home run and four runs were driven in. 

How to make White Sox vs. Yankees picks

SportsLine's model is leaning under on the total, projecting 8.7 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

Who will win Yankees vs. White Sox? And which team has all the value on the money line? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.