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A number of running backs who were backups a few weeks ago are now atop depth charts entering Week 6. Tyler Allgeier, Melvin Gordon and Kenneth Walker III are clear starters due to injuries, while Eno Benjamin and Deon Jackson could get starts on Sunday. That presents plenty of options for Week 6 Fantasy football lineups and sending these players up the Fantasy football rankings. Which players can you trust as you enter your Week 6 Fantasy football picks? Before setting your Fantasy football lineups, be sure to check out the Week 6 Fantasy football rankings from the advanced computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Saints TE Taysom Hill, saying he'd finish as a top-10 player at his position. The result: Hill carried the ball nine times for 112 yards and three touchdowns in Sunday's win over the Seahawks. He also completed a pass for 22 yards and an additional score. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 6 of the 2022 NFL season. Head to SportsLine now to see them.

Top Week 6 Fantasy football picks 

One player the model is high on this week: Packers wide receiver Romeo Doubs. After playing a total of 60 snaps through his first two games, Doubs has averaged 60 snaps per game over his last three. He's now a full-time starter and has averaged 50 yards and scored twice over his last three contests.

Green Bay takes on the Jets on Sunday and just five teams have allowed more TDs to opposing wideouts than New York. Doubs leads the Packers in both targets and receptions, while the top receiver New York has faced has either scored a TD or gone over 100 yards in four of five games. Doubs is a top-20 WR in the Week 6 Fantasy football WR rankings, making him a WR2 in standard-sized leagues. See who else to target here.

And a massive shocker: Eagles wide receiver DeVonta Smith, who's recorded at least 80 receiving yards in three of his last four games, stumbles big-time and doesn't even crack the top 20 at his position. Smith recorded 10 catches for 87 yards in Philadelphia's victory over the Cardinals on Sunday. However, Philadelphia's offense struggled in the second half, scoring just six points in the 20-17 win. 

Smith and the Eagles will now face a stingy Dallas Cowboys defense on Sunday night. The Cowboys are giving up just 14.4 points per game, the third-best mark in the NFL. In addition, Dallas hasn't allowed more than one touchdown pass in a game this season, which doesn't bode well for Smith's Fantasy value this week. With such a tough matchup on Sunday, Smith is a player to consider putting on the bench in Week 6. See who else to fade here.

How to set Week 6 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of its Week 6 Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 6 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has outperformed experts big-time.