The Jacksonville Jaguars will play their NFL-high fourth international game this Sunday, playing at London's Wembley Stadium for the fourth year in a row. The Jags are 1-2 in these games so far, having lost to the 49ers and Cowboys in 2013 and 2014 before defeating the Buffalo Bills last season.

This time around, the Jaguars will play a division game in London for the first time, taking on Andrew Luck and the Indianapolis Colts. Both teams need a win in the worst way. Jacksonville enters the contest at 0-3 while the Colts come in with a 1-2 record.

The AFC South once again looks like the worst division in football, and it's wide open now with the division-leading Texans (2-1) losing J.J. Watt for the entire season. Dropping to 0-4 would seem to be a death knell for Jacksonville's season, while falling to 1-3 with an in-division loss would put the Colts behind the eight-ball as well.

Indianapolis has injury issues all over -- No. 2 receiver Donte Moncrief is out, as are corners Darius Butler and Patrick Robinson -- and has struggled on both sides of the ball this year, but the Jaguars have looked like they should be in the conversation for the NFL's worst team through three weeks. Can either of them get back on track?

How to Watch

  • What: Indianapolis Colts vs. Jacksonville Jaguars
  • When: Sunday, Oct. 2, 9:30 a.m. ET
  • Where: Wembley Stadium, London, England
  • TV: CBS
  • Streaming: Verizon NFL Mobile App
  • Sunday Ticket: DirecTV
  • Online: NFL Game Pass (available to watch online after midnight)
  • Odds: The Colts are currently a -3 favorite according to Bovada.
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The NFL International series kicks off this week in London. USATSI

Injury report

Colts

Jaguars

Prisco's Pick

The Jaguars are off to a rough start, but they still have six games in the division. This is the first. It's a home game for them, but it's also in London. But they aren't playing well. The Colts got their first victory, and they will get the second one here as Andrew Luck plays big.

Pick: Colts 31, Jaguars 23


NFL International Series

The Colts-Jaguars game is the first of four international games the NFL will play this season. Here are the others: