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Wrigley Field showcases the National League Central on Tuesday. The Chicago Cubs welcome the St. Louis Cardinals to town for a doubleheader, with the first game taking place in the early afternoon in Chicago. The matchup is the second game of a five-game midweek series between longtime rivals. Chicago looks to play spoiler against a St. Louis team that currently leads the NL Central by multiple games.

Caesars Sportsbook lists St. Louis as the -195 money-line favorite (risk $195 to win $100) for this 2:20 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over/under, is 8.5 in the latest Cardinals vs. Cubs odds. Before making any Cubs vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 305-263 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Cardinals vs. Cubs and revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's MLB picks. Here are several MLB odds and trends for Cubs vs. Cardinals:

  • Cardinals vs. Cubs money line: Cardinals -195, Cubs +162
  • Cardinals vs. Cubs over/under: 8.5 runs
  • Cardinals vs. Cubs run line: Cardinals -1.5 (-120)
  • STL The Cardinals are 25-20 in day games
  • CHC: The Cubs are 26-24 in day games
  • Cardinals vs. Cubs picks: See picks at SportsLine 
Featured Game | Chicago Cubs vs. St. Louis Cardinals

Why you should back the Cardinals

The Cardinals have a potent offense, but St. Louis also has impressive stability on the mound. Adam Wainwright takes the ball for the Cardinals, and the three-time All-Star right-hander has a 3.11 ERA and a 1.16 WHIP this season. Wainwright is walking only 2.3 batters per nine innings, and he has a .671 OPS allowed. Over the last 10 starts, Wainwright has a 2.85 ERA, and St. Louis is facing a Chicago offense that ranks in the bottom five of the NL in runs scored and strikeouts. 

On the offensive side, the Cardinals have several advantages, including top-five marks in runs scored, hits, home runs, stolen bases and more. St. Louis is also in the top three of the NL in batting average, on-base percentage, slugging percentage and total bases, with MVP candidates Paul Goldschmidt and Nolan Arenado leading the way.

Why you should back the Cubs

The Cubs will have the element of surprise on their side. Chicago is set to deploy Javier Assad, a 25-year old righty, and he is making his Major League debut on the mound. The talented hurler has a 2.66 ERA in the minors, across all levels, this season, and Assad has 111 strikeouts in 111.1 innings. He also has a strong walk rate of only 1.72 per nine innings in Triple-A in 2022, and Assad will have the comfort of home at Wrigley Field. 

On offense, Chicago uses its speed well, ranking in the top three of the National League in triples and stolen bases. The Cubs are slugging more than .400 in home games this season, and Chicago is above the NL average in weighted runs created at Wrigley Field.

How to make Cubs vs. Cardinals picks

SportsLine's model is leaning Over on the total, projecting 9.5 combined runs, and it says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Cardinals vs. Cubs? And which side has all the value? Visit SportsLine now to find out which side of you need to jump on, all from the model that has crushed its MLB picks, and find out.