The San Francisco 49ers can reach numerous franchise milestones on Sunday when they host the upstart Detroit Lions in the 2024 NFC Championship Game. With a victory, the top-seeded 49ers (13-5) will advance to their eighth Super Bowl, tying for second in all-time appearances with the Broncos, Packers and Cowboys. A win would also give them the record for most postseason victories with 37 after they tied the mark with a 24-21 win over Green Bay in the divisional round last weekend. The third-seeded Lions (14-5) will attempt to continue their breakout season by pulling the upset and reaching the Super Bowl for the first time in franchise history.

Kickoff is set for 6:30 p.m. ET from Levi's Stadium. San Francisco is a 7.5-point favorite and the over/under for total points scored is 51.5 in the latest Lions vs. 49ers odds from the SportsLine consensus. Before you make any 49ers vs. Lions picks, you need to see what proven SportsLine NFL expert R.J. White has to say, considering his mastery of picks involving the Lions.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks. He went 535-450-30 on his ATS picks from 2017-22, which returned more than $3,500 to $100 players. 

What's more, he has emerged as SportsLine's top NFL expert again this season, posting a documented record of 97-76-4 on all his NFL picks to net his followers a profit of more than $2,000. White also has a read on the pulse of the Lions. He is 61-43-2 (+1285) on his last 106 picks in games involving Detroit. Anyone who has followed him is way up.

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Now, White has broken down Lions vs. 49ers and just revealed his picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and betting trends for 49ers vs. Lions:

  • 49ers vs. Lions point spread: 49ers -7.5
  • 49ers vs. Lions over/under: 51.5 points
  • 49ers vs. Lions money line: 49ers -348, Lions +276
  • DET: Lions are 3-1 against the spread as betting underdogs this season
  • SF: 49ers are 2-2 ATS as favorites of seven or more points this season
  • 49ers vs. Lions picks: See picks at SportsLine
  • 49ers vs. Lions live stream: fubo (try for free)

Why 49ers can cover

Veteran receiver Deebo Samuel, whose leadership and punishing running style make him invaluable to the 49ers offense, appears to be back on track to play Sunday following a shoulder injury that shelved him for most of last week's game. Many observers noted that the offense appeared out of sync without Samuel in the fold and, even if he isn't at full strength Sunday, his presence as a decoy of sorts will force the Detroit defense to account for him and perhaps create opportunities for other playmakers.

Despite missing two regular-season games because of injuries, the fifth-year pro still managed one of his most productive seasons. The South Carolina product caught 60 passes for 892 yards and seven touchdowns. He also rushed for 225 yards, the second-highest total in his career, while adding five touchdowns on the ground. See which team to pick here.

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Why Lions can cover

There are many motivational factors for Lions quarterback Jared Goff, who has admitted he'd like to silence doubters who believe he will come up short on the big stage. Goff was memorably traded by the Los Angeles Rams after a Super Bowl appearance following the 2018 season in a package deal for Matthew Stafford, who won a championship in his first year under center in Los Angeles.

Meanwhile, Goff went 4-16-1 in his first 21 starts with Detroit, and many observers wondered whether his days as an NFL starter were limited. But Lions coach Dan Campbell has insisted he believes Goff is talented enough to lead the Lions to a Super Bowl and the signal-caller rewarded that faith with perhaps his best overall season. What's more, Goff's return to his Bay Area roots can't be understated. He was a high school star near San Francisco before becoming the top overall pick in the NFL Draft after excelling as a college quarterback for the California Golden Bears. Goff told the media this week he once believed his entire career would be based in California and reaching a Super Bowl by winning in his hometown would make life come full circle. See which team to pick here.

How to make 49ers vs. Lions picks

White has analyzed Lions vs. 49ers from every angle and is leaning Over the point total, but he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

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Who wins Lions vs. 49ers in Sunday's 2024 NFC Championship Game, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Lions vs. 49ers spread hits hard, all from the expert who is 61-43 on picks involving Detroit, and find out.