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An SEC battle is on tap as the LSU Tigers and the Kentucky Wildcats are set to face off at 7:30 p.m. ET on Saturday, October 9 at Kroger Field. UK is 5-0 overall and 4-0 at home, while LSU is 3-2 overall and 1-1 on the road. Kentucky is 4-1 against the spread and LSU is 2-3 ATS in 2021.

Kentucky is favored by three points in the latest Kentucky vs. LSU odds from Caesars Sportsbook, and the over-under is set at 52. Before locking in any LSU vs. Kentucky picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Kentucky vs. LSU and just released its picks and predictions. You can head to SportsLine to see the model's picks. Here are several college football odds and betting lines for Kentucky vs. LSU:

  • Kentucky vs. LSU spread: Kentucky -3
  • Kentucky vs. LSU over-under: 52 points
  • Kentucky vs. LSU moneyline: Kentucky -170, LSU +145

What you need to know about Kentucky

Kentucky has been one of the biggest surprises of the 2021 college football season. With their upset win over Florida last weekend, the Wildcats improved to 5-0 overall and 3-0 in SEC play, which puts them in a tie for first with Georgia in the SEC East.

Kentucky has relied on a dominant rushing attack, led by running back Chris Rodriguez Jr., and a stifling defense that is allowing only 16.8 points and 284.4 yards per game. Don't be surprised if this game is decided by the matchup between Kentucky's rushing attack and LSU's defensive front seven.

What you need to know about LSU

LSU suffered a bitter 24-19 defeat last Saturday, failing to capitalize on an early lead against Bo Nix the Auburn Tigers. A silver lining for LSU was the play of dynamic wide receiver Kayshon Boutte, who caught six passes for one TD and 127 yards.

While they haven't been as dominant as others in recent LSU history, this year's Tigers defense has played fairly well aside from a few hiccups in 2021. Offensively, the Tigers have been wildly inconsistent. One of LSU's biggest issue this fall has been its struggles in the running game, where they are averaging a paltry 70.6 yards per game.

How to make LSU vs. Kentucky picks

The model has simulated Kentucky vs. LSU 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model's LSU vs. Kentucky pick at SportsLine.

So who wins Kentucky vs. LSU? And which side of the spread has all the value? Visit SportsLine now to see which side of the Kentucky vs. LSU spread to jump on, all from the advanced model that is on an 12-4 run on top-rated picks, and find out.