The NFL is a league of slim margins, and that's what makes NFL football office pools so enjoyable. Players can't simply look at the Vegas lines and know who will win a game straight up. In fact, since 2000, over half of NFL contests have been single-possession games, meaning the final margin was eight points or fewer. A majority of games could go either way based on just a few plays. That means anybody making NFL pool picks has a lot to think about on a week-to-week basis. All 16 games on the Week 1 NFL schedule, in fact, have one-possession lines, so getting off to a fast start on NFL picks will be a challenge, much less keeping that momentum all season long. If you're up for it, CBS Sports has the perfect game to keep you locked in all season long.

Compete for $100,000 or start a pool with friends

It's time to raise the stakes with CBS Sports Football Pick'em. Join the challenge to compete for the $100,000 jackpot and guaranteed cash prizes each week or start a customizable pool to compete against your friends. (No purchase necessary. See Terms and Rules for details.)

You can win the $100,000 jackpot each week for hitting the full slate and tiebreakers. Even if no one hits the jackpot, CBS Sports is giving away a guaranteed $1,000 to the winner each week. In addition, the player with the most correct picks at the end of the season gets $5,000.

If you're looking to start a pick'em pool with your friends, family or colleagues, group settings include a variety of games suitable for every fan, including straight-up picks, against-the-spread picks, survivor pools, confidence points and much more. You can play on your desktop or on the CBS Sports app, so sign up here today

Get football picks for every game from a proven NFL model

We'll give you one team to consider backing during the NFL's opening week. SportsLine's advanced computer model, which simulates every NFL game 10,000 times, is predicting the New Orleans Saints take care of business against the Atlanta Falcons in a 1 p.m. ET matchup on Sunday in Atlanta.

The New Orleans passing game should look completely different this season. Jameis Winston is back at quarterback after ending his 2021 season early due to a torn ACL. Michael Thomas also returns after two separate ankle injuries kept him sidelined last year. Additionally, the Saints spent a first-round draft pick on receiver Chris Olave and brought over veteran Jarvis Landry from the Browns in free agency. Running back Alvin Kamara remains one of the best options out of the backfield in the NFL.

Atlanta, meanwhile, had one of the worst defenses in the NFL last season. The Falcons allowed opponents to complete 67.8% of their passes, which made Atlanta the fifth-worst team in the league in that metric. SportsLine's model sees this as a nightmare matchup for Atlanta as New Orleans wins in 70% of simulations, making the Saints a strong play for Week 1 NFL office pool picks. Join a pool now to lock in your picks.

Make NFL pool picks at CBS Sports

Show your skills, beat your friends and coworkers, and take home guaranteed prize money. Create a pool, get your friends involved, and keep the competition going all season long