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The trilogy bout fans have waited nearly two years for is finally here. Two titans of the heavyweight division will clash inside the T-Mobile Arena in Las Vegas on Saturday night for the WBC heavyweight crown when champion Tyson Fury looks for his second win over Deontay Wilder in the main event of an ESPN/FOX PPV.

The two first met back in December 2018 with Fury largely outboxing Wilder throughout the contest. But a pair of knockdowns, including one in Round 12 that seemingly came close to ending the fight, for Wilder earned enough in judges' eyes to rule a draw. Then in February 2020, Fury silenced any doubts by getting inside on Wilder and scoring the seventh-round TKO after Wilder's corner threw in the towel following multiple knockdowns. Now, Wilder looks for revenge after being granted his rematch by an independent arbitrator just before Fury was able to secure a unification bout with then champion Anthony Joshua.

When there's a big fight on tap, just about everyone is going to want to get in on a piece of the action. That's why sportsbooks tend to see a huge influx of bets on big PPV fight nights. With that in mind, we're here to help get you ready with some advice before you place those wagers. We'll take a closer look at each fight on the main card and what you can expect from each fighter.

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Odds below are via Caesars Sportsbook

Main card

Jared Anderson vs Vladimir Tereshkin, heavyweight

  • Odds: Anderson -1500, Tereshkin +800 | Last three results: Anderson - W,W,W | Tereshkin - W,W,W
  • Anderson: America's top heavyweight boxing prospect
  • Tereshkin: A 14-year veteran coming off nearly a two-year layoff

Barring disastrous career turns, Jared "Big Baby" Anderson (9-0, 9 KO) is the future of American heavyweight boxing. The 6-foot-4, 21-year-old carries good athleticism and speed. Anderson has every opportunity to be the kind of complete package America hasn't produced at heavyweight in decades. Tereshkin (22-0-1, 12 KO) is the biggest test of Anderson's career, with a long boxing career that has spanned 14 years and fights across eight countries. Tereshkin is also coming off nearly two years out of the ring and likely was chosen to face a top prospect for a reason -- and that reason doesn't likely include that he's a threat to pull off the victory.

Robert Helenius vs Adam Kownacki, Heavyweight

  • Odds: Kownacki -270, Helenius +220 | Last three results: Kownacki - L,W,W | Helenius - W,W,L
  • Kownacki: Looking to rebound from a shocking upset to Helenius in his most recent fight
  • Helenius: A long-time contender who never reached a shot at the world championship

Helenius and Kownacki met in a March 3, 2020 clash, just before the world changed as the COVID-19 pandemic fully took hold. The fight was supposed to be a big moment for Kownacki (20-1, 15 KO) as he crept closer to a title shot in front of a loud, hometown crowd in Brooklyn. Instead, Helenius (30-3, 19 KO) crushed Kownacki to score a fourth-round TKO in a WBA title eliminator. Helenius, seemingly well-removed from the best days of his career, was thought to be just an opponent for Kownacki. Instead, he took advantage of Kownacki's reckless aggression to score the big upset and breathe new life into his career. Neither man has fought since and Kownacki will enter the ring trying to prove the loss was a fluke while starting what could be a long climb back to a title opportunity.

Frank Sanchez vs. Efe Ajagba, Heavyweight

  • Odds: Sanchez -180, Ajagba +155 | Last three results: Sanchez - W,W,W | Ajagba - W,W,W
  • Sanchez: A tactical Cuban fighter who has been on big stages before
  • Ajagba: Rough around the edges, Ajagba looks to erase some uneven recent performances

This is a fight between undefeated fighters who could both fairly be considered prospects. Sanchez (18-0, 13 KO) is likely the fighter thought to have a higher ceiling coming into the fight with something of a typical "Cuban style" that can occasionally be dull as he picks opponents apart. That style has proven effective, however. Ajagba (15-0, 12 KO) is a talented Nigerian fighter who now fights out of Texas. He has suffered a few scares in his career, including suffering a third-round knockdown against Iago Kiladze in December 2019 before scoring a stoppage in Round 5. This is a huge opportunity for both men, with the chance to prove their spot as legitimate future title contenders and a ton to lose in defeat.

Tyson Fury (c) vs. Deontay Wilder, WBC heavyweight title

  • Odds: Fury -270, Wilder +220 | Last three results: Fury  - W,D,W | Wilder - L,D,W
  • Fury: The undefeated lineal heavyweight champion looking to work toward undisputed status
  • Wilder: One of the hardest-hitting one-punch knockout artists in boxing history

The first fight between Fury and Wilder ended in a controversial draw after most felt Fury deserved the win despite suffering two knockdowns. Fury (30-0-1, 21 KO) left no doubt in the rematch, absolutely dominating Wilder from the opening bell, scoring two knockdowns before the seventh-round stoppage. When he is on, Fury is every bit the best heavyweight in the world he claims to be. Unfortunately, discipline problems have been the biggest issue in Fury's career. With his combination of awkward and effective technique, size and chin, Fury would be the favorite against any heavyweight on the planet, as long as he enters the fight focused.

Wilder (42-1-1, 41 KO) is one of the hardest punchers in the history of boxing. That punching power makes him a danger at every single second of the fight and a fighter who can never be counted out. He proved he has the ability to hurt Fury, with the Round 12 knockdown in the first meeting coming close to stopping the Gypsy King only for Fury to shockingly rise back to his feet to finish out the fight. A loss would be devastating for Wilder, who has gone through nearly every possible conspiracy theory to explain his loss in the rematch, including claiming his own corner was conspiring against him and that Fury cheated by loading -- or removing the padding from -- his gloves.

Who will win Fury vs. Wilder III? And which huge 30-1 prop bet should you be all over? Visit SportsLine now to see Brandon Wise's best bets, all from the CBS combat sports specialist who has crushed his picks, and find out.