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The South Carolina Gamecocks and the Florida Gators are set to square off in an SEC matchup at 7:30 p.m. ET on Saturday, Nov. 6 at Williams-Brice Stadium. The Gamecocks are 4-4 overall and 3-1 at home, while Florida is 4-4 overall and 1-2 on the road. The Gators have won three straight games over the Gamecocks, and lead the all-time series 29-9-3. 

Florida is favored by 19 points in the latest South Carolina vs. Florida odds from Caesars Sportsbook, and the over-under is set at 52.5. Before making any Florida vs. South Carolina picks, you need to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picksagainst the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. Florida and just revealed its coveted Week 10 college football picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for South Carolina vs. Florida:

  • South Carolina vs. Florida spread: South Carolina +19
  • South Carolina vs. Florida over-under: 52 points
Featured Game | South Carolina Gamecocks vs. Florida Gators

What you need to know about South Carolina

South Carolina has to be hurting after a devastating 44-14 defeat at the hands of the Texas A&M Aggies last week. USC was down 41-0 at the end of the third quarter, which was just too much to recover from. 

The Gamecocks have been stout defensively all year, and their talent on that side of the ball is good enough to keep them competitive in most games. Offensively, they have been much more inconsistent, ranking last in the SEC in total yards and averaging only 20.9 points per game. South Carolina is 3-4-1 against the spread in 2021.

What you need to know about Florida

Meanwhile, things couldn't have gone much worse for Florida as they lost 34-7 to the Georgia Bulldogs last Saturday. The Gators were in a tough position by the half, with the score already sitting at 24-0. Their only offensive touchdown came on a rush from quarterback Emory Jones after the game had already been decided.

The Gators continue to have quarterback issues. Jones and Anthony Richardson have both seen the field, but both have been inconsistent. Florida does have an explosive rushing attack, averaging 242.8 yards per game. The Gators are 3-5 against the spread in 2021.

How to make Florida vs. South Carolina picks

The model has simulated South Carolina vs. Florida 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it also says one side of the spread has all the value. You can only see the model's South Carolina vs. Florida picks at SportsLine.

So who wins Florida vs. South Carolina? And which side of the spread holds all the value? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.