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Dustin Poirier gets another chance to capture his first world championship on Saturday night when he takes on lightweight champion Charles Oliveira in the main event of UFC 269. The action goes down from Las Vegas' T-Mobile Arena and airs live on pay-per-view.

There is another title bout set for the night, with the greatest female fighter ever, Amanda Nunes, defending her bantamweight title against Julianna Pena. 

Nunes, champion at both bantamweight and featherweight, defending her 135-pound title against Pena. Nunes has not lost a fight since 2014 while going on arguably the most impressive run in the history of MMA, male or female. Nunes has defeated every woman to ever hold the bantamweight or featherweight titles, including crushing knockouts of Ronda Rousey and Cris Cyborg. Pena, meanwhile, has gone 2-2 since 2017 with both losses coming against former Nunes foes in Valentina Shevchenko and Germaine de Randamie.

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Plus, former bantamweight champion Cody Garbrandt is back in his flyweight debut against Kai Kara-France in a featured bout. Garbrandt, 30, is 1-4 since claiming the 135-pound title in 2016. And another rising star in the bantamweight division "Suga" Sean O'Malley is back when he opens up the PPV against divisional newcomer Raulian Paiva. O'Malley is 4-1 with four knockouts since returning to the Octagon in March 2020.

Earlier on the prelims, former bantamweight champion Dominick Cruz continues his return to action when he takes on Pedro Munhoz. Cruz, 36, was out of action for nearly four years when he returned to a surprise title shot against Henry Cejudo in May 2020, which he lost by TKO. He bounced back with a split decision win over Casey Kenny in March and looks to continue his rebound against Munhoz, who has lost three of his last four to current or former champions.

Below is all the information you need to catch UFC  269 on Saturday night. 

How to watch UFC 269 prelims

Date: Dec. 11 | Location: T-Mobile Arena -- Las Vegas
Time: 8 p.m. ET
Channel: ESPN2 | Stream: fuboTV (try for free)

How to watch UFC 269 main card

Date: Dec. 11 | Location: T-Mobile Arena -- Las Vegas
Time: 10 p.m. ET
Stream: ESPN+ | Price: $69.99

Now, here's a look at the UFC 269 main fight card and betting odds via Caesars Sportsbook.

UFC 269 main card, odds

FavoriteUnderdogWeightclass

Dustin Poirier -140

Charles Oliveira (c) +120

Lightweight title

Amanda Nunes (c) -900

Julianna Pena +600

Women's bantamweight title

Geoff Neal -110

Santiago Ponzinibbio -110

Welterweight

Cody Garbrandt -135

Kai Kara-France +115

Flyweight

Sean O'Malley -310

Raulian Paiva +250

Bantamweight