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Nissan Stadium in Nashville, Tenn., will host Tennessee (7-5) and Purdue (8-4) for the 2021 Music City Bowl on Thursday afternoon. The Volunteers and Boilermakers will battle it out on the gridiron for the second time ever. Both teams are riding two-game winning streaks and hope to end the year with a third consecutive victory. Will Tennessee's dynamic offense be too much for a Purdue squad that is missing some key pieces? 

Kickoff is set for 3 p.m. ET. Caesars Sportsbook lists the Vols as 7.5-point favorites in the latest Tennessee vs. Purdue odds. This has been one of the biggest line moves in bowl season after the Boilermakers opened as the favorites a couple weeks back. The over-under for total points is up to 65.5 after opening at 63. Before locking in any Purdue vs. Tennessee picks or Music City Bowl 2021 predictions, be sure to check out the betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also enters the third week of the 2021-22 college football bowl season on a 43-30 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Tennessee vs. Purdue and locked in its picks and Music City Bowl 2021 predictions. You can visit SportsLine now to see the model's picks. Here are several college football odds and betting lines for Purdue vs. Tennessee:

  • Tennessee vs. Purdue spread: Volunteers -7.5
  • Tennessee vs. Purdue over-under: 65.5
  • Tennessee vs. Purdue money line: Volunteers -270, Boilermakers +220
  • TENN: The Volunteers are 2-4 ATS in their last six games
  • PUR: The Boilermakers are 4-1 ATS in their last five games
Featured Game | Purdue Boilermakers vs. Tennessee Volunteers

Why Tennessee can cover

The Volunteers have scored with ease in 2021. They've tallied 57 total offensive touchdowns and have been just as successful through the air as they have been on the ground. Tennessee has amassed 29 rushing touchdowns and 28 passing touchdowns. While Purdue has an edge through the air, Aidan O'Connell could see a drop in production without his favorite target available.

David Bell has caught 93 passes for 1,286 yards and six scores in 2021. He's accounted for 33 percent of his team's catches and 31 percent of his team's receiving yards, but he has opted out of this game. Purdue scored tied a season-low with 13 points in the one regular-season game Bell missed this year. Picking up the slack against an offensive juggernaut could be too big of an ask for the rest of the Boilermakers' receiving corps. 

Why Purdue can cover 

Purdue covered in seven of its 12 regular-season games. It won ATS on the opposing team's turf three times and is 1-0 ATS at neutral sites in 2021. Playing competitive games away from home isn't new for the Boilermakers.

While Bell accounts for over 30 percent of Purdue's receptions and receiving yards, several other wideouts have been fairly productive. Four players not named Bell have caught at least four touchdown passes this season. It could be difficult for Tennessee to pull away if Purdue's other wideouts step up to support O'Connell. The Boilermakers are 3-3 ATS as underdogs.

How to make Purdue vs. Tennessee picks

SportsLine's model is leaning under on the total, projecting 58 combined points. It has also generated an against-the-spread pick that hits in almost 60 percent of simulations. You can only get the model's Music City Bowl picks at SportsLine

So who wins Tennessee vs. Purdue? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the Purdue vs. Tennessee spread to jump on, all from the computer model that is up almost $3,600 on its top-rated college football spread picks.