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Jim Harbaugh and the No. 5 Michigan Wolverines face a stiff test on Saturday. Michigan takes on James Franklin and the No. 10 Penn State Nittany Lions in Ann Arbor. Michigan is 15-10 all-time against Penn State, and the Wolverines are 4-3 when Harbaugh takes on Franklin. Both teams are unbeaten this season, both overall and in conference games.

Caesars Sportsbook lists the Wolverines as 7-point home favorites for this noon ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 49 in the latest Penn State vs. Michigan odds, down 1.5 points from the opening line. Before making any Michigan vs. Penn State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan vs. Penn State and just locked in its picks and CFB predictions. You can visit SportsLine now to see its picks. Here are the college football odds and betting lines for Penn State vs. Michigan:

  • Michigan vs. Penn State spread: Michigan -7
  • Michigan vs. Penn State over/under: 49 points
  • Michigan vs. Penn State money line: Michigan -285, Penn State +228
  • PSU: The Nittany Lions are 3-2 against the spread this season
  • MICH: The Wolverines are 3-3 against the spread this season
  • Michigan vs. Penn State picks: See picks at SportsLine
Featured Game | Michigan Wolverines vs. Penn State Nittany Lions

Why Penn State can cover

Penn State's offense is playing well to begin the 2022 season. The Nittany Lions are averaging 443.6 total yards per game, a top-five mark in the Big Ten, and Penn State is generating nearly 200 rushing yards per game. Penn State protects the quarterback well, allowing only seven sacks in five games, and Sean Clifford is an established signal-caller. He has 13 touchdowns and only two interceptions in 2022, with Clifford generating six touchdowns and no interceptions in three career games against Michigan. 

On the ground, Penn State has Nicholas Singleton and Kaytron Allen, both of whom are averaging more than 5.0 yards per carry, and Singleton is No. 3 among players in the Power Five in averaging 7.3 yards per tote. On defense, Penn State is on a four-game streak of limiting opponents to 14 points or fewer, and the Nittany Lions are elite against the run, giving up fewer than 80 yards per game and 2.96 yards per carry.

Why Michigan can cover 

Michigan's offense is drawing headlines, and the defense is playing at an elite level. The Wolverines are allowing only 11.3 points and 247.0 total yards per game, both of which rank near the top of the country. Michigan's passing defense is strong, yielding only 165.3 yards per game and 5.1 yards per attempt, and no team in the Big Ten has more sacks (22) than Michigan. The Wolverines are also stingy against the run, ranking No. 7 in the country with 81.7 yards allowed per game, and Michigan is No. 4 among Power Five teams in allowing 2.6 yards per carry. 

On the other side, Michigan is putting up 43.0 points per game and 458.7 total yards per game, and the Wolverines have 20 rushing touchdowns with 5.4 yards per carry. With only eight sacks allowed in six games, Michigan's offensive line is performing well, and the Wolverines lead the Big Ten with a robust 74.1% completion rate. Blake Corum is in the top three of the country in rushing touchdowns (11) and rushing yards (735), and Michigan has real balance and talent to put pressure on opponents.

How to make Penn State vs. Michigan picks

SportsLine's model is leaning Over on the total, projecting 54 combined points. It also says one side of the spread hits almost 60% of the time. Head to SportsLine to see the picks

So who will win Michigan vs. Penn State? And which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the model that has crushed its college football picks, and find out.