Conor McGregor will look to avoid back-to-back losses for the first time in his career when he faces Dustin Poirier at UFC 264 on Saturday at T-Mobile Arena. The main UFC 264 fight card is scheduled to begin at 10 p.m. ET. McGregor has never lost two bouts in a row to the same fighter entering McGregor vs. Poirier 3. The only other time McGregor faced the same opponent in consecutive matches was five years ago against Nate Diaz. After losing by submission in his welterweight debut in March 2016, McGregor came back in August to post a major decision victory.
Poirier is priced at -130 (risk $130 to win $100), while McGregor is at +110 in the latest Conor McGregor vs. Dustin Poirier 3 odds from William Hill Sportsbook. In the co-main event, Stephen Thompson is a -140 favorite in the UFC 264 odds as he takes on Gilbert Burns (+120) in a welterweight bout. Before locking in any McGregor vs. Poirier picks or UFC 264 predictions, make sure you check out the expert MMA picks from SportsLine's Kyle Marley.
Over the past 28 months, $100 bettors who have followed Marley's picks are up more than $15,000. The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 32 of his last 52 UFC main-event picks, a stretch that included a streak of five consecutive underdogs.
At UFC Fight Night last weekend, Marley's winners included Shavkat Rakhmonov over Michel Prazeres and Tim Means over Nicolas Dalby, both in welterweight bouts. Anyone who has followed Marley is way up.
Now, Marley has made the call on Poirier vs McGregor 3 and every other matchup on the UFC 264 fight card. You can only see who to back here.
Conor McGregor vs. Dustin Poirier expert preview
McGregor enters the bout ranked No. 5 in the UFC lightweight division. He is a former UFC featherweight and lightweight double-champion as well as a former Cage Warriors featherweight and lightweight champion. McGregor owns the distinction of recording UFC's fastest knockout, stopping Jose Aldo in 13 seconds of the first round at UFC 194 in December 2015. The victory unified the UFC Featherweight Championship.
Although he has limited success in recent bouts, McGregor remains a formidable opponent. In January 2020, he knocked out Donald Cerrone in 40 seconds of the first round in a welterweight bout at UFC 246. He knocked out Eddie Alvarez for the UFC lightweight championship at UFC 205 in November 2016. He also earned Performance of the Night. He later was stripped of the title due to inactivity, but he later fought Khabib Nurmagomedov in an attempt to regain the title in October 2018. McGregor, however, lost by submission in 3:03 of the fourth round.
Poirier remains as one of the top fighters in UFC and is sixth in the UFC men's pound-for-pound rankings. The American is also the top-ranked fighter in the UFC lightweight division. Poirier has proven to not only be a good boxer, but is also good on the mat. He has a 27-6 career record, with 13 wins by knockout. He also has seven wins by submission and seven by decision.
Poirier's lone loss out of his last seven bouts came in September 2019 for the UFC Lightweight Championship. Poirier was beaten by submission at 2:06 of the third round by Khabib Nurmagomedov at UFC 242 at Abu Dhabi, United Arab Emirates. Poirier wasn't down for long, however. He responded with a unanimous decision win over Dan Hooker in June 2020. Seven months later, he knocked out McGregor at UFC 257. You can see which McGregor vs. Poirier picks to make for the fight here.
UFC 264: Conor McGregor vs. Dustin Poirier predictions
We'll share one of Marley's UFC 264: McGregor vs. Poirier 3 selections here: He is going with Trevin Giles (-110) to get his hand raised against Dricus Du Plessis (-110) in a matchup of middleweight prospects.
Giles (14-2), a Houston police officer, made his UFC debut in 2014, winning by submission over Angelus Raymond McFarlane at Legacy FC 27. He won his first 11 fights of his career before suffering his only two losses of his career in 2019, both by submission. Since that time, he has won his last three fights, including a unanimous decision over Roman Dolidze in March.
Du Plessis (15-2) has also won his last three bouts, including a win by knockout over Markus Perez in October of last year. This will be his first fight in nine months. Prior to the coronavirus pandemic, Du Plessis won the EFC Middleweight Championship in December 2019, when he defeated Brendan Lesar by submission at EFC Africa 83.
"I am going to take Giles to be the aggressor and the one landing the better strikes and takedowns and he can win a decision or get a finish himself," Marley told SportsLine.
How to make UFC 264: Conor McGregor vs. Dustin Poirier picks
Marley also has strong picks for McGregor vs. Poirier and every other fight on the UFC 264 fight card. He's also backing a fighter who's coming in hot to pull off a decision win. You can only get those UFC 264 picks at SportsLine.
Who wins Conor McGregor vs. Dustin Poirier? And how exactly does each fight end? Visit SportsLine now to get detailed picks on every fight at UFC 264, all from the expert who's up more than $15,000 on MMA in the past 28 months, and find out.
UFC 264 odds, fight card
Dustin Poirier (-130) vs. Conor McGregor (+110)
Stephen Thompson (-140) vs. Gilbert Burns (+120)
Tai Tuivasa (-140) vs. Greg Hardy (+120)
Irene Aldana (-145) vs. Yana Kunitskaya (+125)
Sean O'Malley (-800) vs. Kris Moutinho (+550)
Max Griffin (-175) vs. Carlos Condit (+155)
Michel Pereira (-160) vs. Niko Price (+140)
Trevin Giles (-120) vs. Dricus du Plessis (+100)
Ilia Topuria (-240) vs. Ryan Hall (+200)
Jennifer Maia (-190) vs. Jessica Eye (+170)
Brad Tavares (-175) vs. Omari Akhmedov (+155)
Zhalgas Zhumagulov (-400) vs. Jerome Rivera (+320)
Alen Amedovski (-175) vs. Yaozong Hu (+155)