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Novak Djokovic is the most prominent figure in the the 2023 Wimbledon men's singles tournament. He returns to action on Tuesday in a quarterfinal tilt against Andrey Rublev in a quarterfinal matchup. The match is set to begin at 10 a.m. ET, with the winner to meet either Roman Safiullin or Jannik Sinner in the semifinal. Rublev faces an immense challenge against the four-time reigning Wimbledon champion, with Djokovic playing against history.

Djokovic is a -1600 favorite (risk $1600 to win $100) in the latest Djokovic vs. Rublev odds from Caesars Sportsbook, with Rublev getting +800 (risk $100 to win $800) as the underdog. Caesars sets the over/under for total games at 32.5, with Djokovic favored by 6.5 games. Before making any 2023 Wimbledon picks, be sure to check out the latest tennis predictions from proven SportsLine tennis handicapper Jose Onorato

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the United States, he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players. Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bets. He studies current form, a player's tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach helped Onorato go 96-67-7 -- up 60.42 units -- in 2022.

Now, Onorato has locked in on the 2023 Wimbledon men's quarterfinal matchup featuring Djokovic vs. Rublev and revealed his best bets. He's sharing all of his picks and analysis at SportsLine.

Top Djokovic vs. Rublev predictions

Djokovic is operating at an extremely high level. The 36-year-old has won four straight Wimbledon titles and 32 consecutive matches in the tournament. Djokovic is already the men's record holder with 23 grand slam titles, and he is looking to surpass Serena Williams for the all-time record of 24. He is 90-10 at Wimbledon and is looking to win a fifth straight title at a single major event for the first time. Djokovic defeated Hubert Hurkacz in four sets to advance to the quarterfinal and, incredibly, he has won 25 straight matches in grand slam competition. He is also 3-1 all-time against Rublev, including a straight-set win in their last meeting. 

Rublev, the No. 7 seed, is the ninth active player to reach at least the quarterfinal in all four grand slam events. He was impressive in a five-set win over Alexander Bublik, including a pivotal shot that created a permanent highlight. Rublev also has a slight rest advantage in this setting, and Djokovic has been forced to a tiebreaker in five of eleven sets in the tournament. Djokovic is a dominant tiebreaker player, but variance can increase in that narrow environment. See who to pick here.

How to make Djokovic vs. Rublev picks

In addition to his full breakdown of the match, Onorato has released a best bet for the match. You can only see Onorato's Wimbledon picks and analysis at SportsLine.

What is the best bet for Djokovic vs. Rublev in the 2023 Wimbledon men's quarterfinal? Visit SportsLine now to see Onorato's best bet for Djokovic vs. Rublev, all from the elite tennis handicapper who has crushed his Grand Slam tennis picks, and find out.