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Louisiana Tech will open the 2022 season under a new head coach after it replaced Skip Holtz with former Texas Tech offensive coordinator Sonny Cumbie in the offseason. Cumbie will be up against a tough challenge when the Bulldogs travel to Missouri for Thursday night's season opener. The Tigers are entering their third year under head coach Eli Drinkwitz, who is looking to take a step forward this season. 

Kickoff is set for 8 p.m. ET. The Tigers are 19.5-point favorites in the latest Louisiana Tech vs. Missouri odds from Caesars Sportsbook, while the over/under for total points scored is 60.5. Before making any Louisiana Tech vs. Missouri picks, you need to see the college football predictions and betting advice from the proven simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Missouri vs. Louisiana Tech. You can head to SportsLine to see its picks. Here are several college football odds for Louisiana Tech vs. Missouri:

  • Missouri vs. Louisiana Tech spread: Missouri -20.5
  • Missouri vs. Louisiana Tech over/under: 61.5 points
  • Missouri vs. Louisiana Tech money line: Missouri -1400, Louisiana Tech +800
  • Missouri vs. Louisiana Tech picks: See picks here.

Why Missouri can cover

Louisiana Tech is having to start over under a new head coach this season, which does not bode well for a team that is winless in its last nine games against SEC schools. The Bulldogs were terrible down the stretch last season, losing seven of their final eight games. They have returning production on the defensive side of the ball, but that unit ranked outside the top 100 nationally in total defense. 

Missouri has been excellent in season openers over the last decade-plus, going 14-2 in its last 16 Week 1 games. The Tigers covered the spread in four of their final five games last season, giving them some confidence heading into their 2022 campaign. They have more speed, talent and strength than Louisiana Tech, making them a strong wagering option on Thursday night. 

What Louisiana Tech can cover

This is a large spread for a Missouri team that has to answer some questions at several key positions on offense. The Tigers relied heavily on their star running back last season, but he is no longer on the roster. They are also replacing their starting quarterback, so it will be difficult for them to get the offense rolling in Week 1. 

Louisiana Tech made a splash in the transfer portal when it was able to snag former TCU quarterback Matthew Downing. He is working alongside several returning wide receivers and has an offensive-minded head coach at the helm. The defense returns most of its key production as well, so that unit is expected to take a step forward this season. 

How to make Missouri vs. Louisiana Tech picks

The model has simulated Missouri vs. Louisiana Tech 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Louisiana Tech vs. Missouri? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to find out which side of the Missouri vs. Louisiana Tech spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.