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One of college football's most bitter rivalries is set to renew on Saturday when the No. 3 Michigan Wolverines host the No. 2 Ohio State Buckeyes in The Game on Saturday at Michigan Stadium. The winner of this matchup will punch its ticket to the Big Ten Championship Game against Iowa, and likely the College Football Playoff. The Wolverines are coming off a 31-24 win over Maryland, and will once again be without head coach Jim Harbaugh (suspension). The Buckeyes are looking to keep things rolling after blowing out Minnesota 37-3 in their last outing. Michigan leads the all-time series 60–51–6, with wins in the last two years.

Kickoff is set for noon ET at Michigan Stadium. The Wolverines are 3-point favorites in the latest Michigan vs. Ohio State odds via SportsLine consensus, while the over/under is 46. Before locking in any Ohio State vs. Michigan picks, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has been red-hot all season, going 70-28-2 overall on his college football best bets for SportsLine this season so far. He is up over 43.05 units, returning a profit of $4,305 for $100 bettors. Anyone who has followed his picks this season is way up.

Now, he has set his sights on Ohio State vs. Michigan and just locked in his picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Michigan vs. Ohio State:

  • Ohio State vs. Michigan spread: Michigan -3
  • Ohio State vs. Michigan over/under: 46
  • Ohio State vs. Michigan money line: Michigan -153, Ohio State +128
  • MICH: The Wolverines are 5-5-1 against the spread in 2023.
  • OSU: The Buckeyes are 6-2-2 against the spread in 2023.
  • Ohio State vs. Michigan picks: See picks at SportsLine
  • Ohio State vs. Michigan live stream: fubo (try for free)

Why Michigan can cover

Ohio State has struggled as an underdog in recent years, going 1-3 straight up and 2-2 against the spread in its last four games in that role since 2019. The Buckeyes are traveling to one of the most difficult atmospheres in the country, as Michigan is riding a 21-game home winning streak. The Wolverines have been profitable in those games, covering the spread at an 11-8-2 clip with an average margin of victory of 28 points per game.

They have become accustomed to playing without Harbaugh on the sidelines, so that should not be an issue on Saturday. The Wolverines rank first nationally in total defense and scoring defense, giving up just 7.2 points per game at home. Their offense has scored at least 30 points in six home victories, and they cruised to a 45-23 win at Ohio State last year. See which team to pick at SportsLine

Why Ohio State can cover

As has become the norm over the last decade, Ohio State is one of the most talented overall teams in college football. The Buckeyes are typically known for their offensive firepower, but this year's team is led by a stifling defense. OSU enters this matchup ranked No. 2 in the country in points allowed per game (9.3), and leads college football in passing defense, allowing 144.4 yards per game.

Offensively, the Buckeyes are led by running back TreVeyon Henderson and wide receiver Marvin Harrison Jr.. Henderson has rushed for 794 yards and 10 touchdowns, while Harrison, who is widely considered to be the best overall player in the country, has 62 catches for 1,093 yards and 13 touchdowns. Ohio State ranks third in the Big Ten, averaging 33.6 points per game in 2023. See which team to back at SportsLine.

How to make Michigan vs. Ohio State picks

Kaylor has analyzed this matchup from every angle and he's leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Michigan vs. Ohio State on Saturday, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see the picks, all from the expert who has covered college football for over a decade and is 70-28-2 on his best bets in 2023, and find out.