The Syracuse Orange (2-0) host the Purdue Boilermakers (1-1) in a non-conference matchup that helps kick off the Week 3 college football schedule on Saturday. These teams played once before in 2004, where Purdue torched Syracuse 51-0. The Boilermakers are 4-1 ATS in their last five games overall. Meanwhile, the Orange are 6-1 ATS in their last seven home games.

Kickoff is at noon ET from JWA Wireless Dome in Syracuse, N.Y. Caesars Sportsbook lists the Orange as 1.5-point favorites in the latest Purdue vs. Syracuse odds. The over/under for total points is set at 60. Before locking in any Syracuse vs. Purdue picks, be sure to check out the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Purdue vs. Syracuse and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Now, here are several college football odds and trends for Syracuse vs. Purdue:

  • Purdue vs. Syracuse spread: Syracuse -1.5 
  • Purdue vs. Syracuse over/under: 60 points  
  • Purdue vs. Syracuse money line: Boilermakers +105, Orange -125
  • PUR: Boilermakers are 4-1 ATS in their last five games overall 
  • SYR: Orange are 6-1 ATS in their last seven home games 
  • Purdue vs. Syracuse picks: See picks here
Featured Game | Syracuse Orange vs. Purdue Boilermakers

Why Syracuse can cover

The Orange have a nice collective group of pass catchers to help out quarterback Garrett Shrader. Sophomore running back Sean Tucker is a soft-handed receiver coming out of the backfield. He's first on the team in catches (10) and receiving yards (101). Senior receiver Devaughn Cooper is a deep threat weapon who can stretch the field for this offense. He's snagged seven passes for 87 yards with 12.4 yards per reception.

Sophomore Oronde Gadsden II is looking to carve a larger role within this offense. Gadsden II is a big-boded weapon (6-foot-5) with the physicality to be a force in the red zone. The Florida native is third on the team in catches (6) and receiving yards (81). In Week 1 against Louisville, he caught three passes for 36 yards with a touchdown. 

Why Purdue can cover

Purdue has played solid defensively through the first two games. This unit hasn't allowed teams to impose their will and run the football. They are currently ranked fifth in the Big Ten in rushing yards allowed per game (74.5) with just 2.2 yards per carry. Junior safety Sanoussi Kane has already made an impact.

Kane leads the team in total tackles (10) with a forced fumble. The New York native can play in the box and provide the Boilermakers with a physical hitter. Senior safety Cam Allen is another strong presence in the secondary. Allen is solid in coverage with the ability to make plays on the ball. The Virginia native is second on the team in tackles (8) along with two pass deflections and a 65-yard interception return for a score. 

How to make Purdue vs. Syracuse picks

SportsLine's model is leaning Under on the total, projecting the teams to combine for 50 points. The model also says one side of the spread hits in almost 60% of simulations. You can only get the model's pick at SportsLine

So who wins Purdue vs. Syracuse? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.