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USC officially introduced former Oklahoma head coach Lincoln Riley as the program's next head coach on Monday. Riley went 55-10 with the Sooners, appearing in three College Football Playoffs in his five seasons at the helm. It'll be interim head coach Donte Williams, however, leading USC in its regular-season finale. The Trojans (4-7) will wrap up their lackluster 2021 campaign with a rescheduled tilt at California (4-7) on Saturday night. The teams were originally scheduled to meet in November, but that game was postponed by a COVID-19 outbreak.

Kickoff is set for 11 p.m. ET. The Golden Bears are 4.5-point favorites in the latest USC vs. California odds at Caesars Sportsbook, while the total is 57.5. Before entering any USC vs. California picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Cal vs. USC. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for USC vs. Cal:

  • USC vs. California spread: California -4.5
  • USC vs. California over-under: 57.5 points
  • USC vs. California money line: California -200, USC +170
Featured Game | California Golden Bears vs. USC Trojans

What you need to know about California

There is no bowl berth on the line for either team, so motivation becomes a key aspect of this handicap. California has covered the spread in four of its last six games, while USC has covered in one of its last six games. The Golden Bears have one last chance to send their seniors out on a high note, which gives them a motivational edge at home.

California's defense has been solid this season, holding opposing quarterbacks to a 58.4 percent completion rate. The Golden Bears have also recorded 13 interceptions, with three separate players picking off three passes. USC has lost five of its last six games and is clearly looking ahead to the future.

What you need to know about USC

USC has several positives to build on heading into this game, including the announcement of Riley as head coach. The Trojans have already secured several high-level recruits that flipped from Oklahoma this week. They are also coming off one of their best performances of the season, taking then-No. 13 BYU down to the wire in a 35-31 final.

The Trojans have not lost in Berkeley since 2003 and they have won 15 of the last 16 matchups between these teams. Freshman quarterback Jaxson Dart made the second start of his career last week, completing 23 of 35 passes for 248 yards and a touchdown. Dart also rushed for another touchdown, while running back Vavae Malepeai totaled 99 rushing yards of his own.  

How to make California vs. USC picks

The model is leaning under on the point total, and it also says one side of the spread hits well over 60 percent of the time. You can only see the pick at SportsLine.

So who wins USC vs. Cal? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college football picks, and find out.