Tolbert (hamstring) has been ruled out for Sunday's game against the Patriots, Chris Brown of the Bills' official site reports.
Tolbert will be sidelined for the third contest in a row, leaving Travaris Cadet to continue backing up LeSean McCoy. Cadet has been effective in a change-of-pace role the last couple of weeks and could retain the No. 2 spot on the depth chart at running back even once Tolbert is healthy again.