MLB: Milwaukee Brewers at San Francisco Giants
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Dodgers starter Tony Gonsolin can become the National League's first 15-game winner when he takes the mound on Wednesday against the Milwaukee Brewers at American Family Field. Gonsolin (14-1, 2.24 ERA) has won three straight starts since losing his only game of the season, on July 25 against the Nationals. Los Angeles (80-35) is a -178 favorite in the latest Dodgers vs. Brewers odds from Caesars Sportsbook, while Milwaukee (62-53) is a +150 underdog.

First pitch is set for 8:10 p.m. ET in Milwaukee. The game is one of 15 on the MLB schedule for Wednesday. Elsewhere in the majors, the Mets and Braves meet in the third game of their important four-game series in Atlanta and the White Sox look to win their sixth straight game, against the Astros. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 300-260 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of well over 20-1. You can see the model's MLB picks only at SportsLine

Top MLB picks today

The model, which ran 10,000 simulations on each of Wednesday's games, likes the Chicago White Sox (+122) to knock off Houston. The White Sox (61-56) are in a dogfight in the AL Central, just one game behind the division-leading Guardians and tied with the Twins for second. Chicago is five games over .500 for the first time this season.

White Sox first baseman Jose Abreu is on a roll. In his last four games, he is 9-of-14 (.643 batting average) and has scored three runs. For the season he leads the team in batting average (.307), home runs (14), on-base percentage (.382) and OPS (.847), while ranking second in RBI (65) and slugging percentage (.466). See who else to back right here.

Featured Game | Chicago White Sox vs. Houston Astros

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a play on a big National League underdog. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of well over 20-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 300-260 run on top-rated MLB money-line picks since the start of 2021.